Samaneh Sabouri; Mohsen Foroughipour; Elaheh Emadi; Daryoush Hamidi Alamdari
Abstract
Introduction: In multiple sclerosis (MS), oxidative stress (OS) performs a vital role in the neurodegeneration process. Cholesterol and lipids in the myelin sheath supplied by low-density lipoprotein (LDL) are also vital for nerve cells. In OS, lipid peroxidation occurs in LDL. Objective: To investigate ...
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Introduction: In multiple sclerosis (MS), oxidative stress (OS) performs a vital role in the neurodegeneration process. Cholesterol and lipids in the myelin sheath supplied by low-density lipoprotein (LDL) are also vital for nerve cells. In OS, lipid peroxidation occurs in LDL. Objective: To investigate the OS biomarker such as prooxidant-antioxidant balance (PAB), malondialdehyde (MDA) and their correlation with LDL and oxidized LDL (Oxi-LDL) in patients with relapsing-remitting MS.Methods: Blood samples from 18 patients with relapsing-remitting MS and 18 healthy subjects were collected to measure the OS biomarkers.Results: In the patients' group in comparison to the control group: PAB, white blood cells (WBC), and neutrophils significantly increased (P<0.05), but there was no difference between the relapsing and remitting phase; MDA significantly increased in the relapsing phase (P=0.013), but marginally significant in remitting (P=0.068). There was no significant difference in LDL and Oxi-LDL between the two groups. Only the lymphocytes were different between the relapse and remission phases. Conclusion: The importance of OS in the process of MS disease was confirmed and a PAB assay can be used for the determination of OS levels.
Mohsen Ebrahimi; Mohammadreza Shirzadeh; Mohsen Foroughipour; Hamid Zamani Moghadam; Mona Najaf Najafi; Mahdi Foroughian
Abstract
Background: According to statistics, at least four percent of people experience one or more nonfebrile seizures in their life span. Continuous Electroencephalography (cEEG) Monitoring is a useful diagnostic tool for seizure detection. The purpose of this study was to investigate EEG findings in first-time ...
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Background: According to statistics, at least four percent of people experience one or more nonfebrile seizures in their life span. Continuous Electroencephalography (cEEG) Monitoring is a useful diagnostic tool for seizure detection. The purpose of this study was to investigate EEG findings in first-time seizure patients referred to emergency department (ED). Methods: The present cross-sectional study was conducted on 80 first-time seizure patients admitted to ED, who were selected by convenience sampling method. The inclusion criteria were all patients aged more than 17 years with first-time seizure and informed written consent to participate in the study, and the exclusion criteria were cases where the seizure was not confirmed by a neurologist. An EEG was taken in the ED from the patient within 24 hours of the first attack. Finally, the frequency of pathological changes in EEG findings was determined in these patients. The statistical data were analyzed by SPSS software using descriptive statistics (measures of central tendency and dispersion and frequency distribution) and inferential statistics. Results: The patients consisted of 35 (43.8%) males and 45 (56.2%) females. The patients had a mean age of 52.54±19.33 years and a median of 53 years. Among the patients, 46 (57.5%) had normal EEG findings, and 34 (42.5%) had abnormal (pathological) EEG findings. Conclusion: According to the results of this study, 42.5% of patients had abnormal EEG findings, but it seems that accurate examination would require the use of other diagnostic tools along with EEG to diagnose patients with epilepsy and seizure more precisely.