%0 Journal Article %T Clinical significance of DVM and its prevalence in pre-gestational diabetes cases versus normal pregnancies %J Reviews in Clinical Medicine %I Mashhad University of Medical Sciences %Z 2345-6256 %A Akhlaghi, Farideh %A Akhondzadeh, Mahnaz %D 2015 %\ 07/01/2015 %V 2 %N 3 %P 135-137 %! Clinical significance of DVM and its prevalence in pre-gestational diabetes cases versus normal pregnancies %K Maturation %K Mortality %K Placental villi %K pregnancy %K Pre-gestational diabetes mellitus (PGDM) %R 10.17463/RCM.2015.03.006 %X Pre-gestational diabetes mellitus affects less than 1% of all pregnancies and is a significant cause of fetal morbidity and mortality. It is hypothesized that impaired placental function, in the form of abnormal placental weight and/or abnormal placental histology, may be responsible for this event in such pregnancies. Delayed villous maturation of placental villi, which is one of the findings associated with pre-gestational diabetes increases the rate of perinatal mortality. There is limited literature regarding the delayed maturation of placental villous. This review included trials (randomized and non-randomized), cohort and case-control studies registered in Medline/PubMed database, from January 2001 to September 2012 that evaluated the clinical significance of delayed villous maturation and its prevalence in pre-gestational diabetic cases compared to normal pregnancies.It emphasizes that further studies with focus on possible clinical or ultrasound markers of placental delayed villous maturation, especially in a high risk-group such as women with pre-gestational diabetes mellitus are highly recommended. %U https://rcm.mums.ac.ir/article_4341_2042b0f81f2130f6684d7b9555869376.pdf