TY - JOUR ID - 10481 TI - Therapeutic Updates on Lichen planopilaris and Frontal Fibrosing Alopecia: A Systematic Review JO - Reviews in Clinical Medicine JA - RCM LA - en SN - 2345-6256 AU - Bakhshoudeh, Behnoush AU - Salehi, Maryam AU - Sadeghi, Ramin AU - Omranzadeh, Alireza AU - Sahranavard, Toktam AU - Arekhi, Soheil AU - Jafarzadeh Esfehani, Ali AU - Zabolinejad, Naghmeh AD - Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AD - Associate Professor of Community Medicine, Research Center for Patient Safety, Mashhad University of Medical Science, Mashhad, Iran and Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran AD - Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AD - Student of Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2018 PY - 2018 VL - 5 IS - 3 SP - 76 EP - 94 KW - Frontal fibrosing alopecia KW - Lichen planopilaris KW - Treatment DO - 10.22038/rcm.2018.30338.1228 N2 - Introduction: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are skin diseases that affect the quality of life. Although a systematic review on LPP and FFA treatment was published in 2013, further updates are needed. The aim of this study is to review systematically the studies published after the last systematic review.Methods: We searched Scopus, PubMed, Embase, and ISI Web of Science. All the studies published during March 2012-June 2017 were included in this review. Two reviewers separately selected the studies and extracted the data. The results of studies were categorized as unimproved, stabilized, and improved based on the articles reports.Result: Among the 38 studies, 20, 17, and one studies assessed LPP, FFA, and both treatments, respectively. The papers were case reports, case series, cohorts, and randomized controlled trials. Antimalarial agents and pioglitazone resulted in enhancement in 73 and 71% of the LPP patients, respectively. Improvement and stabilization were observed in almost one third of the topical steroid users and 6/12 of Tacrolimus/Pimecrolimus users in LPP. Improvement and stabilization in FFA was found in 68% of the individuals using antimalarial agents, 83% of intralesional steroid users, all cases of finasteride users, and 95% of the people utilizing dutasteride.Conclusion: Contrary to the previous systematic review, we found antimalarial agents more effective than steroids in LPP. Finasteride/dutasteride may have favorable impacts on FFA. Intralesional steroids showed to be more effective than antimalarial agents in FFA. Still further studies are needed in order to define a treatment protocol. Low quality and heterogeneity of the articles were among the limitations for making a conclusion. UR - https://rcm.mums.ac.ir/article_10481.html L1 - https://rcm.mums.ac.ir/article_10481_a3c1bc618f8ceeef9503f4835fa6b640.pdf ER -