TY - JOUR ID - 2201 TI - The effect of Tranexamic acid on cardiac surgery bleeding JO - Reviews in Clinical Medicine JA - RCM LA - en SN - 2345-6256 AU - Esmaeelzadeh, Mohammad AU - Amini, Shahram AD - Department of Anesthesiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2014 PY - 2014 VL - 1 IS - 1 SP - 7 EP - 11 KW - Bleeding KW - Blood transfusion KW - Cardiac Surgery KW - Tranexamic acid DO - 10.17463/RCM.2014.01.003 N2 - Serious bleeding in cardiac surgery leads to re-exploration, blood transfusion and increases the risks of mortality and morbidity. Using the lysine analogous of antifibrionlytic agents are the preferred strategy to suppress the need for transfusion procedures and blood products. Although tranexamic acid has been very influential in reducing the transfusion requirement after operation, tranexamic acid induced seizures is one of the common side effects of this drug. Due to inhibiting the fibrinolysis, thrombotic events are other possible side effects of using tranexamic acid. There are no certain results regarding decreasing the mortality rate by using the drug but it is identified that tranexamic acid does not increase the mortality. In this article, we aimed to review the literature on using tranexamic acid in cardiac surgeries. UR - https://rcm.mums.ac.ir/article_2201.html L1 - https://rcm.mums.ac.ir/article_2201_8d02266e309d03389e3114411e703ce6.pdf ER -