TY - JOUR ID - 3089 TI - Glioblastoma and the significance of MGMT gene methylation JO - Reviews in Clinical Medicine JA - RCM LA - en SN - 2345-6256 AU - Izadpanahi, Payam AU - Anvari, Kazem AU - Fazl Ersi, Mitra AD - Solid Tumor Treatment Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2014 PY - 2014 VL - 1 IS - 3 SP - 135 EP - 140 KW - chemotherapy KW - Glioblastoma KW - MGMT gene KW - Radiotherapy KW - Temozolomide DO - 10.17463/RCM.2014.03.008 N2 - In this research Glioblastoma has been studied as one of the most common brain tumors and a short review of the available therapeutic methods have presented including surgery, radiotherapy, chemotherapy and particularly adjuvant chemotherapy with temozolomide, as the most effective developed treatment. Moreover, MGMT gene promoter methylation has been introduced as an important predictive factor of treatment response to temozolamide. The different mechanisms of methylation and the available literature on its association with patient survival and disease recurrence have been summarized. Taken together, Glioblastoma is a tumor in which the MGMT gene expression can potentially deliver the highest amount of data in comparison to other tumors; as almost every related study has emphasized on the direct association between MGMT methylation and patient survival. Regarding this debate, the pseudoprogression pattern in Glioblastoma patients and the laboratory methods studying MGMT gene methylation have been examined. At the end of this review, the obstacles to its development have been briefly mentioned. UR - https://rcm.mums.ac.ir/article_3089.html L1 - https://rcm.mums.ac.ir/article_3089_0aedea96dbf552ac2850b13b9dc09c3d.pdf ER -