TY - JOUR ID - 3255 TI - Medical treatment for hepatopulmonary syndrome: a systematic review JO - Reviews in Clinical Medicine JA - RCM LA - en SN - 2345-6256 AU - Zarifmahmoudi, Leili AU - Khalesi, Maryam AU - Sadeghi, Ramin AU - Jafari, Seyed Ali AU - Kiani, Mohammad Ali AU - Kianifar, Hamidreza AD - Clinical Research Development Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran AD - Department of Pediatrics, Ghaem Hospital, Mashhad University of medical sciences, Mashhad, Iran AD - Nuclear Medicine Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran AD - Department of Pediatrics Gastroenterology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2014 PY - 2014 VL - 1 IS - 4 SP - 165 EP - 175 KW - Hepatopulmonary syndrome KW - Liver disease KW - Pentoxifylline DO - 10.17463/RCM.2014.04.001 N2 - Introduction: Hepatopulmonary syndrome (HPS) is known as a chronic liver disease associated with severe pulmonary deoxygenation due to intrapulmonary vascular vasodilation. Although liver transplantation is accepted as a main treatment of HPS, identifying effective drugs for recovery of HPS can be effective in postponing the transplantation and decreasing the mortality rate of patients before the transplantation. In this study we briefly reviewed the pathogenesis of HPS and also systematically reviewed the current pharmacological treatment of HPS. Method: Pubmed, Scopus, and Google scholar were searched for the relevant English language clinical and experimental articles about the medications used in the treatment of HPS. Results: A total of 38 articles were included in this study which mostly resulted in decreasing NOS expression, NO production, endothelin-1 activation, intrapulmonary angiogenesis and increasing oxygenation.Conclusion: Various drugs have been proposed in treatment of HPS but more large controlled trial studies, is necessary to determine the exact efficacy of each drugs for HPS recovery. UR - https://rcm.mums.ac.ir/article_3255.html L1 - https://rcm.mums.ac.ir/article_3255_707890e285326fced35f7604fbc508e1.pdf ER -