Association of HLA-DRB1 with recurrent Aphthous Stomatitis in Northeast Iranian population

Document Type: Original article

Authors

1 Oral and Maxillofacial Disease Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Inflammation and Inflammatory Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Department of Oral and Maxillofacial Diseases, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran

4 Oral and Maxillofacial Disease Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

5 Oral & Dental Disease Research Center, Department of Oral & Maxillofacial Pathology, School of Dentistry, Zahedan University of Medical Science, Zahedan, Iran

6 Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.

7 Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran

8 Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

10.22038/rcm.2020.50604.1330

Abstract

Introduction: Recurrent aphthous ulcers are the most common pathologic conditions of the oral cavity, which despite having clear clinical features, the etiology is unknown. This study aimed to determine the relationship between one of the histocompatibility antigens (HLA DRB1) and its sub-groups with the incidence of recurrent aphthous ulcers in an Iranian population (North East of Iran).
Materials and methods: In this case-control study, a total of 72 patients with recurrent aphthous ulcers and 70 healthy subjects in Northeast Iranian populationwere included. Genotyping was done by polymerase chain reaction-specific sequence primers (PCR- SSP) for each sample, according to standard kit protocol (BAG- Germany).
Results: In 72 patients with recurrent aphthous ulcers that were included in this study, 26 were male and 46 were female; of the 70 control patients, this difference not significant statistically (P>0.05). The frequency of HLA -DRB1 * 16 was 0.7% in the healthy subjects, however frequency of HLA -DRB1 * 16 in patients with recurrent aphthous stomatitis (RAS) was 42.36%, and this difference was statistically significant (P=0.03). But, this difference was not observed in other subgroups.
Conclusion: The frequency of DRB1 * 16 in the patients with RAS were higher than the group. Therefore, DRB1 * 16 can be suggested as a Predisposing factor for aphthous ulcers patients.

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