1Cardiology department,Quaem Hospital,Mashhad University of Medical Sciences,Mashhad, Iran
2Cardiology Department,Quaem Hospital,Mashhad University of Medical Sciences,Mashhad, Iran
3Department of Cardiology,Ghaeem Hospital
Introduction: The pathophysiology of ischemia involves the cellular effect of myocardial ischemia, reactive oxygen species, and Reactive inflammatory enzymes to form cascade. Left atrial (LA) ischemia has been shown to have several possible mechanisms through which it can lead to abnormalities in left ventricular filling in early diastole and thus reduce LA passive functional reserve. In this review study, we evaluated the physiological mechanisms of LA during myocardial ischemia, as previously demonstrated in experimental and clinical studies.
Methods: Several databases were searched in order to find related articles. The outcome of interest included LA function measurements (measurement of left atrial volume) during ischemia. By applying a standardized protocol, reviewers independently abstracted and assessed the studies.
Results: The literature review indicated 50 publications, among which 15 studies were eligible for analysis. Articles reporting outcomes from the same study were included once in the analysis. Discussion: Assessment of LA dimension and function is essential for clinical evaluation and prognostic purposes. In the present article, it was revealed that LA passive emptying volume and LA emptying volume significantly increased in myocardial ischemic patients.
Conclusion: Further research could provide a better understanding of pathophysiological mechanisms behind LA enlargement and help predict clinical outcomes in many cardiovascular disorders.