Relationship between heart failure with preserved ejection fraction and thyroid disorders: Review of the Literature

Document Type: Systematic review

Authors

1 Department of Cardiology, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Cardiology, Emam Reza Hospital, Mashhad, Iran.

Abstract

Introduction: Heart failure with preserved ejection fraction may be combined with some other disease or as a result of dysfunction in their normal performance. Thyroid dysfunctions and abnormal thyroid hormone levels may be in close relation with heart problems, and may be indicators of future heart failure.

Methods: Scopus and PubMed were searched methodically using "thyroid disorders" and "heart failure with preserved ejection fraction" as search terms on April 2015 to find articles with English language in which the association between thyroid disorders and heart failure with preserved ejection fraction (HFPEF) had been evaluated. Full text of all relevant articles was comprehensively reviewed and used for data extraction.

Results: Of total 51 articles found in PubMed, 34 records found in Scopus and 3 articles found through reference list screening, only 13 papers fully met the inclusion criteria for further assessment. A total of 2135 patients participated in the included literatures, 1450 were male and 595 were female.
Discussion: Results of studies show that cardiac and thyroid functions are in close relationship, in which the level of thyroid hormone, predominantly T3 level can be considered as an independent prognostic factor in HFPEF. Moreover, findings suggested that thyroid hormones level can be considered as predictors for mortality due to HF.

Conclusion: Based on the results obtained in the included documents, there may be association between thyroid disorders and thyroid hormone levels with cardiac complications, particularly heart failure with preserved ejection fraction.

Keywords