1Department of Gastroenterology and Hepatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Gastroenterology and Hepatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad
3Department of Gastroenterology and Hepatology, School of Medicine Mashhad University of Medical Sciences, Mashhad, Iran
Background Hepatitis E infection, which is cause by the hepatitis E virus (HEV), is a self-limiting disease with moderate to high prevalence in different areas. Since Iran is one of the areas where HEV is endemic, the aim of this study was to systematically review the prevalence of HEV in Iran. Methods A systematic search was performed on May 2016 in the PubMed, Scopus and IranMedex using following search method (((Hepatitis E OR HEV)) AND (epidemiology OR frequency OR prevalence)) AND Iran to investigate the prevalence of Hepatitis E infection in Iran. After collection of the appropriate documents, the desired data were extracted and described. Results A total of 24 relevant articles with overall 12555 study population were collected. The results of this review showed that the prevalence of HEV was rather high among Iranian population. The prevalence of HEV varied between 2.3% to more than 40% among the studies. Conclusion Findings of this study showed that HEV prevalence is as same as those reported in other developing countries. The results of this study also necessitate the need to perform routinely diagnostic tests for the diagnosis of hepatitis E, especially in suspected cases of acute hepatitis.