Reza Ibrahimi; Shadab Sahraian; AmirAli Moodi Ghalibaf; Mahnaz mozdorian
Abstract
Coronavirus disease 2019 (COVID-19) is a rapidly growing health concern claiming over 6 million lives as of April 2022. Some evidence revealed that pregnancy increases the risk of severe illness with Coronavirus infection. COVID-19 also complicates the pregnancy results such as the number of cesarean ...
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Coronavirus disease 2019 (COVID-19) is a rapidly growing health concern claiming over 6 million lives as of April 2022. Some evidence revealed that pregnancy increases the risk of severe illness with Coronavirus infection. COVID-19 also complicates the pregnancy results such as the number of cesarean deliveries and premature births. Mitral stenosis is a structural heart disease that endangers the patient and their newborn, accompanied by serious morbidity and mortality. The present patient, 40 years old gravida 2 para 1 at 37 weeks presented to the emergency department with progressive dyspnea following fever and malaise for a week. SARS-CoV-2 testing was positive ergo appropriate treatment was administered. CT scan showed severe COVID-19 pneumonia with a severity index of 23. Due to respiratory distress, the patient was readily admitted to the intensive care unit. The patient was supported with non-invasive ventilation. Nevertheless, NIV was insufficient with signs of respiratory fatigue so the patient was intubated. Despite the subsidence of fever and stable clinical condition patient remained tachycardic which promoted us to perform echocardiography revealing severe mitral stenosis. This report contains our experience and suggestions regarding this rare concurrence. The paucity of data is significant regarding the management of concurrent structural heart disease and COVID-19 in pregnancy. It should be emphasized that the importance of maintaining routine care and screening during the pandemic; which can be catastrophic if missed.
Hamideh Ebrahimi Gore; Ali Taghizadeh; AmirAli Moodi Ghalibaf; Ali Shamshirian; Mohammad Reza Motie
Abstract
Introduction: The breast cancer burden is still increasing, both in developing and developed countries. The present study was conducted to determine the survival rate of breast cancer based on tumor biological subtypes in patients referring to three referral oncology centers at Mashhad University of ...
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Introduction: The breast cancer burden is still increasing, both in developing and developed countries. The present study was conducted to determine the survival rate of breast cancer based on tumor biological subtypes in patients referring to three referral oncology centers at Mashhad University of Medical Sciences, Mashhad, Iran.Methods: The present population-based study was conducted at Imam Reza Hospital, Omid Hospital, and Reza Oncology Center, Mashhad University of Medical Sciences, Mashhad, Iran Demographic information, the status of biomarkers in immune-histochemical evaluation, clinical and pathological features of the tumor, type of therapy, recurrence, or death was recorded for each eligible patient.Results: In total, 247 patients were included in the study. The mean age of patients was 48.8 ± 1.3 years. The mean time of survival was 2.64±0.13 years. In detail, the survival rate from the first year to the fifth year was reported as 100%, 96%, 91%, 90%, and 89%, respectively. The survival rate of the luminal B subtype was higher than other subtypes but the difference was not significant (P=0.7). Only in terms of metastasis, there was a significant difference between the alive and dead patients (P=0.0001).Conclusion: Despite no significant relationship between biological markers, the breast cancer subtype, and its survival rate, the overall survival rate of the patients decreased lightly through five years. However, further studies are required to indicate more accurate data about the breast cancer survival rate in our region.
Saeedeh Talebi; Payam Sharifan; Andisheh Norouzian Ostad; Seyedeh-Elaheh Shariati; AmirAli Moodi Ghalibaf; Mehdi Barati; Malihe Aghasizadeh; Sahar ghoflchi; Hamideh Ghazizadeh; Niloofar Shabani; Gordon A. Ferns; Hamid Reza Rahimi; majid Ghayour
Abstract
Introduction: Chamomile (Matricaria chamomilla L.), as widely used as a medicinal herb and is brewed beverages, and has been used for the treatment of several conditions. The evidence from in vitro, in vivo, and clinical studies suggests that chamomile and its many flavonoid components have anti-oxidant ...
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Introduction: Chamomile (Matricaria chamomilla L.), as widely used as a medicinal herb and is brewed beverages, and has been used for the treatment of several conditions. The evidence from in vitro, in vivo, and clinical studies suggests that chamomile and its many flavonoid components have anti-oxidant and anti-inflammatory properties. This review aimed to provide an overview of the chemical constituents of chamomile and the effectiveness of the chamomile preparations and several of its constituents for the treatment of several medical conditions. Methods: The present comprehensive review study was conducted by searching electronic databases including Scopus, Web of Sciences, Embase, and PubMed, using relevant keywords. Results: Both animal and human studies indicate the positive effects of chamomile on the antioxidant enzyme activity. However, the mechanisms involved in the action of chamomile against the production of ROS remain still unknown. When it comes to its anti-inflammatory properties, a number of in vitro, in vivo, and clinical investigations have been reported regarding to the selective inhibition of COX-2, suppression of NO production, prevention of IL-1β, IL-6 and TNFα-induced NO levels, reduction of iNOS mRNA and protein expression, impediment of leukocyte adhesion and adhesion protein up-regulation in human endothelial cells, and blockage of IL-1 α-induced prostaglandin production, TNF-α-induced IL-6 and IL-8 release. Conclusions: Current studies suggest that chamomile and its flavonoid components have anti-oxidant and anti-inflammatory properties. On the basis of the existing evidences, chamomile appears to ameliorate several diseases caused by oxidative stress as well as inflammatory reactions.