@article { author = {Sadeghian, Mohammad Hadi and Rezaei Dezaki, Zahra and Shams, Seyyede Fatemeh and Shakeri, Sepideh}, title = {Correlation between Human Herpes virus 8 (HHV8-) and Plasma Cell Myeloma: a Systematic Review}, journal = {Reviews in Clinical Medicine}, volume = {5}, number = {3}, pages = {95-100}, year = {2018}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-6256}, eissn = {2345-6892}, doi = {10.22038/rcm.2018.32149.1235}, abstract = {Introduction: Plasma cell myeloma is the distortion of differentiated B lymphocytes which is associated with uncontrolled proliferation of plasma cells in bone marrow. Some studies propound a role for HHV-8 virus in pathogenesis of plasma cell myeloma. Yet the findings are inconsistent. In this article we reviewed the literatures to determine the HHV-8 virus role in plasma cell myeloma pathogenesis.Methods: In this systematic review, scientific databanks including PubMed, Scopus, Embase, ISI, and Google scholar were searched. The search was based on the subsequent keywords and medical terms in title; different combinations of keywords were used, they were compatible with MeSH terms.Result: Four articles declared that there is no link between the HHV-8 and the pathogenesis of plasma cell myeloma; while five reported a connection between the virus and myeloma, arguing that virus infection will lead to disease progression.Conclusion: There are differences between the results of the studies. It is required to do further researches about the association of HHV-8 and plasma cell myeloma.}, keywords = {Etiology,Human herpes virus 8,Multiple Myeloma}, url = {https://rcm.mums.ac.ir/article_11668.html}, eprint = {https://rcm.mums.ac.ir/article_11668_6946da6be5614e96c479f95d50d2efb6.pdf} }