Mashhad University of Medical Sciences
Reviews in Clinical Medicine
2345-6256
2345-6892
8
4
2021
12
01
Antimicrobial Agents in Malignant Otitis Externa: A Systematic Review
145
159
EN
Mohamad Reza
Afzalzadeh
0000-0001-9549-9833
Sinus and Surgical Endoscopic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
doceditinfo@gmail.com
10.22038/rcm.2021.60083.1374
This systematic review determined the main antimicrobial agents resulting in MOE<br />and spectrum antimicrobial therapy covering drug resistance in the disease. All the<br />articles published in three electronic databases, including PubMed, Web of Science,<br />and MEDLINE, were searched within November 15 to December 15, 2020. Eventually,<br />27 reports were identified assessing the clinical outcomes of patients with MOE.<br />Generally, the mean age of patients with MOE in different studies was within the<br />range of 59–82 years, and the male/female ratio was 1.8:1. The frequency of diabetes<br />among patients with MOE was within the range of 40%-100%, and the frequency of<br />facial nerve involvement was up to 60.7% in various studies. Pseudomonas aeruginosa<br />is the most commonly reported causative organism in MOE. Methicillin-resistant<br />Staphylococcus aureus is another organism leading to MOE. The main concerning<br />issue in antibiotic therapy is the increasing isolation of bacterial strains resistant to<br />this therapeutic approach. Generally, patients undergoing initial combination therapy<br />have better outcomes compared to those receiving single therapy. Furthermore, the<br />risk of ciprofloxacin resistance increased, especially when used as a monotherapy<br />agent. The early diagnosis and treatment of patients with MOE are very crucial. In<br />this regard, it is necessary to consider the management of diabetes for controlling<br />the infection with antibiotics and debridement of necrotic tissue. Aggressive surgical<br />management is suggested in some patients with MOE.
Diabetes, Facial Nerve Involvement,Malignant External Otitis,Pseudomonas aeruginosa
https://rcm.mums.ac.ir/article_19307.html
https://rcm.mums.ac.ir/article_19307_10f5ce4146f86057710b6953f4b764df.pdf
Mashhad University of Medical Sciences
Reviews in Clinical Medicine
2345-6256
2345-6892
8
4
2021
12
01
Functional Outcome of Tibial Platue Fracture Treated by Locking Compression Plate- A Prospective Study
160
165
EN
Narendra
Kumar
Central institute of Orthopaedics, VMMC& Safdarjung hospital, Delhi
(FIRST AUTHOR)
narendrakumar168@yahoo.com
Binay
Kumar
Sahu
Department of Orthopaedics, P.S.R.I. Hospital, New Delhi
(second author)
drbinaykumarsahu@gmail.com
Deepak
Kumar
Sharma
0000-0002-2781-0228
Central institute of orthopaedics, VMMC and Safdarjung hospital, Delhi
(Third and corresponding author)
deepakmlbmc@rediffmail.com
10.22038/rcm.2021.57833.1368
<strong>Introduction:</strong> Tibial plateau fractures represent the fractures involving the articular surface of proximal part of the tibia bone i.e. lateral or medial condyle or both, and with varying degrees of articular depression and displacement.Fixation by locking plates has led to dramatic improvement in the treatment of tibial plateau fractures.<br /><strong>Method:</strong> It was a prospective study conducted on 30 patients with tibial plateau fractures at a tertiary care hospital in New Delhi, India. Patients were operated with locking compression plates and followed up for 18 months. Union was checked with serial radiographs and functional outcome was assessed with Rasmussen Functional Knee Score.<br /><strong>Result:</strong> Twentynine patients achieved union at a mean time of 13.65 weeks, one patient had infective nonunion. Overall mean Rasmussen Functional Knee Score was 27 which is graded as excellent.<br /><strong>Conclusion: </strong>Treatment of tibial plateau fractures with open reduction and plating with locking compression plates provides anatomical reduction and desirable functional outcome. Union is earlier and functional results are better for Schatzker type 1-3 when compared to type 4-6. Return to work with greater capacity largely depends on motivation.
Tibial plateau fractures,Locking Compression Plate,Schatzker type,Rasmussen functional score
https://rcm.mums.ac.ir/article_18940.html
https://rcm.mums.ac.ir/article_18940_ebda59cc0f4fc64d8f4e97c408a46d23.pdf
Mashhad University of Medical Sciences
Reviews in Clinical Medicine
2345-6256
2345-6892
8
4
2021
12
01
Effect of Licophar Pills on the Postoperative Sore Throats in Patients Undergoing Cataract Surgery with Laryngo-Pharyngeal Mask Implantation: A Randomized Clinical Trial
166
170
EN
Mohammad
Alipour
0000-0002-0458-0407
Department of Anesthesiology,Mashhad University of Medical Sciences,Mashhad,Iran
alipourm@mums.ac.ir
Vida
Jahanian
0000-0003-0097-6743
Anesthesiology department, Medical faculty, Mashhad University of Medical Sciences, Mashhad, Iran
vida_197900@yahoo.com
Zahra
Momtaz Kaffash
Anesthesiology department, Medical faculty, Mashhad University of Medical Sciences, Mashhad, Iran
m.momtazkaffash@yahoo.com
Elham
Bakhtiari
0000-0002-1582-3961
Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
bakhtiarie@mums.ac.ir
Abolfazl
Akbari
0000-0002-3974-3018
Student research committee, faculty of medicine, Mashhad university of medical sciences, Mashhad, Iran
masteraa1379.ir@gmail.com
10.22038/rcm.2022.63161.1392
<strong>Introduction:</strong> The use of a laryngeal mask airway is associated with complications, such as a sore throat. This study aimed to evaluate the effect of taking the licophar pill on reducing sore throat due to laryngeal mask implantation in cataract surgery candidates.
<strong>Methods: </strong>In this study, 241 patients over 18 years of age with cataract surgery and ASA Ι or ΙΙ were randomly divided into the intervention and control groups. The intervention group received one licophar pill half an hour before surgery; however, the control group received nothing. The sore throat severity was measured 1, 3, 6, 12, and 24 h after surgery using the Visual-Analogue Scale (VAS). The data were analyzed in SPSS software (version 16).
<strong>Results:</strong> Out of 241 patients, 120 cases received licophar pills. There was no significant difference between the two groups in terms of gender; however, the mean age was lower in the control group. On the other hand, the rate of sore throat was significantly higher in the control group, compared to the intervention group. In addition, postoperative pain scores in the intervention vs. control group 1, 3, 6, 12, and 24 h were 0.466 (1.454) vs. 3.842 (3.359), 0.383 (1.298) vs. 3.280 (3.056), 0.275 (1.102) vs. 2.694 (2.580), 0.200 (0.890) vs. 2.074 (2.271), and 0.108 (0.574) vs. 1.429 (1.714), respectively. Moreover, 103 and 40 patients in the intervention and control groups reported no pain (VAS=0), respectively, 1 h after surgery.
<strong>Cocclusion: </strong>The present study showed that the use of licophar lozenge half an hour before surgery has a significant effect on reducing postoperative sore throat.
Laryngeal mask airway,Sore throat,Licophar,Licorice,Postoperative pain
https://rcm.mums.ac.ir/article_19662.html
https://rcm.mums.ac.ir/article_19662_8aceae356dc82d47b6fdac535dd2bd95.pdf
Mashhad University of Medical Sciences
Reviews in Clinical Medicine
2345-6256
2345-6892
8
4
2021
12
01
Inducing Vascular Anastomosis for Vascular Tissue Transplantation and Vascular Regeneration: In Vitro Models and Factors
171
179
EN
Shirin
Saberianpour
0000-0002-5511-2750
Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
saberianpoursh@mums.ac.ir
Jamal
Jalili Shahri
Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
jalilisj@mums.ac.ir
10.22038/rcm.2021.62065.1383
Anastomosis is a term which means a connection between two tubes or branched passages.Veins and arteries connect to transport blood in the body and this connection is natural anastomosis Whenever a blood vessel becomes blocked anastomosis is a backup pathway for blood flow. As the number of patients with chronic organ failure is increasing there is also a rapid increase in the demand for organ transplantation. As a result of a complicated mechanisms in different studies , activation of some factors including FLT1 (Fms Related Receptor Tyrosine Kinase 1), macrophages, fibroblast, hypoxia, platelet drive growth factor, fibrin-based tissue ,mature vessel networks ,VEGF( Vascular endothelial growth factor) and mechanical processes are been inducing factors for vascular anastomosis. Certainly, vascular anastomosis models are necessary for in vitro vascular anastomosis formation to cover vessels with perivascular cells in a microfluidic device or discover new surgery techniques. In this study, an attempt was made to collect effective factors in inducing vascular anastomosis.
Anastomosis,Vascular,Regeneration,Angiogenesis
https://rcm.mums.ac.ir/article_19381.html
https://rcm.mums.ac.ir/article_19381_cc8e83315bc6a09e0bdd5f57f33b0626.pdf
Mashhad University of Medical Sciences
Reviews in Clinical Medicine
2345-6256
2345-6892
8
4
2021
12
01
A comprehensive Review of Amyotrophic Lateral Sclerosis Including: Prevalence, Pathogenesis, Biomarkers Diagnosis, and Current Treatment Options
180
184
EN
Najmeh
Malekzadeh
0000-0002-7780-0650
Department of Genetics, Faculty of Science, Sistan and baluchestan university ,Zahedan,Iran
najmehmalekzadeh@yahoo.com
10.22038/rcm.2022.57207.1365
Amyotrophic lateral sclerosis (ALS) also known as motor neuron disease is a destroying neurodegenerative disease that mainly affects the upper and lower motor neurons. It is now believed that primary diagnosis and treatment are essential and useful. Early diagnosis with newer methods prevents the progression of the disease and allows you to choose the right treatment at a more appropriate time. Earlier and more efficient treatment becomes visible to significantly improve the prognosis of this disease. In this article, we define the disease and the methods of diagnosing it, Then the mechanisms of the disease and treatment options based on these are described. ultimately the old and new methods for treatment ALS were reviewed. These methods include: small molecule, nanotechnology, protein therapy, gene therapy, bone marrow transplantation, stem cell therapy, miRNA therapy and gene editing. The purpose of this review article is to help diagnose and select a suitable treatment and improve patients more effectively.
ALS,Treatment,Diagnosis
https://rcm.mums.ac.ir/article_19466.html
https://rcm.mums.ac.ir/article_19466_a291ba0696867a7a8f290b51524bad77.pdf
Mashhad University of Medical Sciences
Reviews in Clinical Medicine
2345-6256
2345-6892
8
4
2021
12
01
Clinical trial the MSCs therapy in limb ischemia: Choose the Best Method
185
190
EN
Shirin
Saberianpour
0000-0002-5511-2750
Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
saberianpoursh@mums.ac.ir
10.22038/rcm.2021.62276.1385
There is a substantial amount of data provided in preclinical research and recently made early clinical efforts to evaluate the positive MSC therapy in Limb ischemia disease impacts. The present review is primarily focused on assessing various limb ischemia-related human MSC clinical trials to select the best technique with the highest limb ischemia-related clinical trial MSC efficacy. Five studies met the criteria to be included in this review. MSCs originating from bone marrow Allogenic MSC, bone marrow autogenous MSCs, HUCB MSCs were administered. The injection was intramuscular, Intravenous, and intravenous. The mean follow-up time was between 6 to 60months after MSC therapy. All studies reported improvement from baseline in at least 1 clinical outcome measure, and no study reported major adverse events attributable to MSC therapy. In clinical assessments, the selection of the best method could improve treatment efficacy. Several factors may be involved in the MSC injection efficacy of limb ischemia patients. Both allogeneic and autologous exhibited positive results over placebo. However, it is should be mentioned that autologous MSC investigation has higher cost and toxicity. To reduce the toxicity of derived MSCs while injection, particularly in arterial and intravenous injection, different injection doses can be performed. MI injection at different doses is the best method for diminishing the side effects. To evaluate injection efficacy, different criteria can be adopted, including angiography, ABI index, ulcer healing and amputation, and pain-free walking distance follow-up for up to five years.
Mesenchymal stem cells,Ischemia,Therapy,Bone Marrow Transplantation
https://rcm.mums.ac.ir/article_19382.html
https://rcm.mums.ac.ir/article_19382_40a68771b31e96e3c85c3d29a72ccd1f.pdf
Mashhad University of Medical Sciences
Reviews in Clinical Medicine
2345-6256
2345-6892
8
4
2021
12
01
Misdiagnosed Aicardi Goutières Syndrome Patient: A Case Report
194
196
EN
Mohammad Moein
Vakilzadeh
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
vakilzadeh.moein@gmail.com
Najmeh
Ahangari
Next Generation Genetic Polyclinic, Mashhad, Iran.
Department of Modern Sciences and Technologiesm Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
ahangarin951@mums.ac.ir
Ehsan
Ghayoor Karimiani
0000-0003-38587073
Next Generation Genetic Polyclinic, Mashhad, Iran.
Honorary Researcher, University of Manchester, UK
eghayoor@gmail.com
Mehran
Beiraghi Toosi
0000-0002-0569-1117
Pediatric Neurology Department, Ghaem hospital, Mashhad University of Medical Sciences, Mashhad, Iran
beiraghitm@gmail.com
10.22038/rcm.2022.56005.1357
Aicardi Goutiere’s syndrome is an autosomal recessive neurodegenerative disorder. Its clinical signs usually mimic TORCH-like clinical signs; which makes the differential diagnosis difficult. Here, we report a case with one homozygous pathogenic mutation c.529G>A p.Ala177Thr on RNASEH2B gene (NM_024570) that relates to Aicardi-Goutieres syndrome type 2 that had been misdiagnosed in about 5 years.
Aicardi Goutieres,Neurogenetics,Next Generation Sequencing
https://rcm.mums.ac.ir/article_19664.html
https://rcm.mums.ac.ir/article_19664_eb0de6b0f266be97d767a4f32e84b763.pdf