TY - JOUR ID - 11668 TI - Correlation between Human Herpes virus 8 (HHV8-) and Plasma Cell Myeloma: a Systematic Review JO - Reviews in Clinical Medicine JA - RCM LA - en SN - 2345-6256 AU - Sadeghian, Mohammad Hadi AU - Rezaei Dezaki, Zahra AU - Shams, Seyyede Fatemeh AU - Shakeri, Sepideh AD - Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Y1 - 2018 PY - 2018 VL - 5 IS - 3 SP - 95 EP - 100 KW - Etiology KW - Human herpes virus 8 KW - Multiple Myeloma DO - 10.22038/rcm.2018.32149.1235 N2 - Introduction: Plasma cell myeloma is the distortion of differentiated B lymphocytes which is associated with uncontrolled proliferation of plasma cells in bone marrow. Some studies propound a role for HHV-8 virus in pathogenesis of plasma cell myeloma. Yet the findings are inconsistent. In this article we reviewed the literatures to determine the HHV-8 virus role in plasma cell myeloma pathogenesis.Methods: In this systematic review, scientific databanks including PubMed, Scopus, Embase, ISI, and Google scholar were searched. The search was based on the subsequent keywords and medical terms in title; different combinations of keywords were used, they were compatible with MeSH terms.Result: Four articles declared that there is no link between the HHV-8 and the pathogenesis of plasma cell myeloma; while five reported a connection between the virus and myeloma, arguing that virus infection will lead to disease progression.Conclusion: There are differences between the results of the studies. It is required to do further researches about the association of HHV-8 and plasma cell myeloma. UR - https://rcm.mums.ac.ir/article_11668.html L1 - https://rcm.mums.ac.ir/article_11668_6946da6be5614e96c479f95d50d2efb6.pdf ER -