TY - JOUR ID - 13967 TI - Role of Polyunsaturated Fatty Acids in Cancer and Their Use in Cancer Treatment JO - Reviews in Clinical Medicine JA - RCM LA - en SN - 2345-6256 AU - Baran, Yusuf AU - Ulu, Gizem Tuğçe AU - Kiraz, Yağmur AD - Molecular Biology and Genetics, İzmir Institute of Technology, 35433, Urla, İzmir Y1 - 2019 PY - 2019 VL - 6 IS - 3 SP - 84 EP - 90 KW - Polyunsaturated Fatty Acids KW - N-3 Fatty Acids KW - Metabolic Pathways DO - 10.22038/rcm.2019.40236.1276 N2 - Cancer is defined as uncontrolled cell division, which could spread or invade various tissues. There are more than 200 types of cancer, including breast, skin, lung, colon, and prostate cancer, and lymphoma, the symptoms and indications of which vary depending on the type of tissues. Cancer has several treatments with different applications. For instance, chemotherapy, radiation therapy, surgery or their combination are common treatment modalities for cancer. However, a complete cure for cancer has not been achieved yet. On the other hand, novel drugs for cancer treatment are not efficient due to the ability of cancer cells to develop resistance against chemotherapeutic agents. Recently, natural compounds have been reported to improve the efficiency of cancer treatment. Polyunsaturated fatty acids (PUFAs) are natural compounds that could be used as dietary supplements in cancer patients. PUFAs are classified into two main categories, including n-3 and n-6 PUFAs. According to the literature, n-3 PUFAs exert protective effects against cancer through the induction of apoptotic pathways and suppressing cell proliferation, while n-6 PUFAs cause tumor formation by inducing cell growth and proliferation. Using PUFAs in combination with chemotherapeutic agents is considered to be an effective approach to the treatment of cancer patients through increasing cancer cell death. This review aimed to discuss the interactive effects of the structure and function of PUFAs on cancer and cell processes through various signaling pathways.  UR - https://rcm.mums.ac.ir/article_13967.html L1 - https://rcm.mums.ac.ir/article_13967_702dded6906e9f149529866df08771cf.pdf ER -