TY - JOUR ID - 19307 TI - Antimicrobial Agents in Malignant Otitis Externa: A Systematic Review JO - Reviews in Clinical Medicine JA - RCM LA - en SN - 2345-6256 AU - Afzalzadeh, Mohamad Reza AD - Sinus and Surgical Endoscopic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Y1 - 2021 PY - 2021 VL - 8 IS - 4 SP - 145 EP - 159 KW - Diabetes, Facial Nerve Involvement KW - Malignant External Otitis KW - Pseudomonas aeruginosa DO - 10.22038/rcm.2021.60083.1374 N2 - This systematic review determined the main antimicrobial agents resulting in MOEand spectrum antimicrobial therapy covering drug resistance in the disease. All thearticles published in three electronic databases, including PubMed, Web of Science,and MEDLINE, were searched within November 15 to December 15, 2020. Eventually,27 reports were identified assessing the clinical outcomes of patients with MOE.Generally, the mean age of patients with MOE in different studies was within therange of 59–82 years, and the male/female ratio was 1.8:1. The frequency of diabetesamong patients with MOE was within the range of 40%-100%, and the frequency offacial nerve involvement was up to 60.7% in various studies. Pseudomonas aeruginosais the most commonly reported causative organism in MOE. Methicillin-resistantStaphylococcus aureus is another organism leading to MOE. The main concerningissue in antibiotic therapy is the increasing isolation of bacterial strains resistant tothis therapeutic approach. Generally, patients undergoing initial combination therapyhave better outcomes compared to those receiving single therapy. Furthermore, therisk of ciprofloxacin resistance increased, especially when used as a monotherapyagent. The early diagnosis and treatment of patients with MOE are very crucial. Inthis regard, it is necessary to consider the management of diabetes for controllingthe infection with antibiotics and debridement of necrotic tissue. Aggressive surgicalmanagement is suggested in some patients with MOE. UR - https://rcm.mums.ac.ir/article_19307.html L1 - https://rcm.mums.ac.ir/article_19307_10f5ce4146f86057710b6953f4b764df.pdf ER -