TY - JOUR ID - 19466 TI - A comprehensive Review of Amyotrophic Lateral Sclerosis Including: Prevalence, Pathogenesis, Biomarkers Diagnosis, and Current Treatment Options JO - Reviews in Clinical Medicine JA - RCM LA - en SN - 2345-6256 AU - Malekzadeh, Najmeh AD - Department of Genetics, Faculty of Science, Sistan and baluchestan university ,Zahedan,Iran Y1 - 2021 PY - 2021 VL - 8 IS - 4 SP - 180 EP - 184 KW - ALS KW - Treatment KW - Diagnosis DO - 10.22038/rcm.2022.57207.1365 N2 - Amyotrophic lateral sclerosis (ALS) also known as motor neuron disease is a destroying neurodegenerative disease that mainly affects the upper and lower motor neurons. It is now believed that primary diagnosis and treatment are essential and useful. Early diagnosis with newer methods prevents the progression of the disease and allows you to choose the right treatment at a more appropriate time. Earlier and more efficient treatment becomes visible to significantly improve the prognosis of this disease. In this article, we define the disease and the methods of diagnosing it, Then the mechanisms of the disease and treatment options based on these are described. ultimately the old and new methods for treatment ALS were reviewed. These methods include:  small molecule, nanotechnology, protein therapy, gene therapy, bone marrow transplantation, stem cell therapy, miRNA therapy and gene editing. The purpose of this review article is to help diagnose and select a suitable treatment and improve patients more effectively. UR - https://rcm.mums.ac.ir/article_19466.html L1 - https://rcm.mums.ac.ir/article_19466_a291ba0696867a7a8f290b51524bad77.pdf ER -