TY - JOUR ID - 3661 TI - Preventive and therapeutic effects of tranexamic acid on postpartum bleeding JO - Reviews in Clinical Medicine JA - RCM LA - en SN - 2345-6256 AU - Solltani, Samaneh AU - Mirteimouri, Masoumeh AU - Movahedian, Ameneh AU - Chalakinia, Nushin AD - Department of Gynecology & Obstetric, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2015 PY - 2015 VL - 2 IS - 1 SP - 37 EP - 41 KW - Blood loss KW - Cesarean section KW - Postpartum Hemorrhage KW - Tranexamic acid KW - Vaginal delivery DO - 10.17463/RCM.2015.01.009 N2 - Postpartum hemorrhage is among the leading causes of maternal mortality throughout the world. Severe blood loss contributes to  the increased blood transfusion risk with its concerned inherent adverse events and therefore increased rate of emergency re-operative interventions such as arterial ligation or hysterectomy. It also can lead to protracted anemia, particularly in low or median income countries. Extended application of antifibrinolytic agents such as tranexamic acid has been customary for long years to stop or reduce blood loss in postpartum period. However, there are not enough reliable evidence to approve the real efficacy of these drugs. In this brief and summary review, we pointed to a few conducted studies. The PubMed was searched for keyword including postpartum hemorrhage, tranexamic acid, cesarean section, vaginal delivery, and blood loss prevention. The articles with language other than English were excluded from our review.  We concluded that more convincing information is needed to determine the precise effects of tranexamic acid, and its benefits against adverse effects. UR - https://rcm.mums.ac.ir/article_3661.html L1 - https://rcm.mums.ac.ir/article_3661_fbb41fe1d831f7c66d0938d17b16498a.pdf ER -