<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Reviews in Clinical Medicine</title>
			<title_fa></title_fa>
			<short_title>RCM</short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://rcm.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2345-6256</journal_id_issn>
			<journal_id_issn_online>2345-6892</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2020</year>
				<month>9</month>
				<day>1</day>
			</pubdate>
			<volume>7</volume>
			<number>3</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Effect of N-Acetylcysteine on Positive and Negative Syndrome Scale associated with Schizophrenia: A Meta-Analysis</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Meta- analysis</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Background and objective: N-acetylcysteine (NAC), a precursor of L-cysteine with antioxidant, anti-inﬂammatory and neurotropic effects, is a promising agent in alleviating symptoms associated with schizophrenia.  However, the role of NAC on parameters of Positive and Negative Syndrome Scale (PANSS) remain uncertain. This systematic review and meta-analysis explored the effect of NAC on parameters of PANSS in patients with chronic schizophrenia. Methods: We searchedPubmed/MEDLINE™, PsycNET™, PsycLIT™, Scopus™ and Google Scholar™  for studies on the effect of NAC on PANSS in patients with schizophrenia from inception to March 2019. We adopted medical and non-medical subjects headings (MeSH, non-MeSH) and several keywords, including  “NAC”, “N-acetylcysteine”, “N-acetyl cysteine”, “Acetylcysteine”, “N-Acetyl-L-cysteine”,  “schizophrenia”, “psychotic disorder”, “psychosis”, “schizoaffective” and “dementia praecox”. Results: We identified seven trials with274 patients meeting the inclusion criteria, with follow up between 8-52 weeks, and NAC supplementation between 1200-3600 mg/day. Significant improvements in PANSS were identified following NAC for total (SMD=-0.61, 95% CI = -0.91, -0.31 ; p &lt;0.001), general (SMD = -0.58; 95% CI = -0.90, -0.26; P=0.0004); and negative (SMD = -0.56; 95% CI = -0.92, -0.21; P = 0.001) scores, respectively. No significant heterogeneity was found among studies. Significant reductions were observed following sub-group analysis in trials ≤ 24 weeks duration, with appreciable effect size for total (SMD= -0.83), general (SMD= -0.67) and negative (SMD=-1.09) scores. Conclusion: Supplementation of NAC was effective in alleviating PANSS symptoms associated with schizophrenia in trials ≤ 24 weeks duration. The use of NAC as an adjunct seems promising and further investigation is warranted to determine its precise role.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>NAC, Positive and Negative Syndrome Scale (PANSS), Schizophrenia, Systematic review, RCTs, Meta-analysis</keyword>
				<start_page>134</start_page>
				<end_page>144</end_page>
				<web_url>https://rcm.mums.ac.ir/article_16843.html</web_url>
			<author_list><author>
				<first_name>Amir</first_name>
				<middle_name></middle_name>
				<last_name>Ghaderi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>gaderiam@yahoo.com</email>
				<code>71950</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Addiction studies, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Anna</first_name>
				<middle_name></middle_name>
				<last_name>Bussu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>anna.bussu@edgehill.ac.uk</email>
				<code>71951</code>
				<coreauthor>No</coreauthor>
				<affiliation>Faculty of Health, Social Care and Medicine, Applied Health and Social Care, Edge Hill University, Ormskirk, Lancashire, United Kingdom.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Catherine</first_name>
				<middle_name></middle_name>
				<last_name>Tsang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>catherine.tsang@northumbria.ac.uk</email>
				<code>71952</code>
				<coreauthor>No</coreauthor>
				<affiliation>Faculty of Health and Life Sciences, Health Applied Sciences, Northumbria University, Newcastle, United Kingdom.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sadegh</first_name>
				<middle_name></middle_name>
				<last_name>Jafarnejad</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sjafarnejad@alumnus.tums.ac.ir</email>
				<code>71953</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>