Mehrnaz Nazarirad; Nasrin Moazzen; Mojtaba Lotfi
Abstract
Mucopolysaccharidosis is a group of progressive metabolic disease (lysosomal storage) characterized by the deposition of glycosaminoglycans in the body, affecting various organs including the skeletal system, (dysostosis multiplex), viscera (hepatomegaly and splenomegaly), neurological complications, ...
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Mucopolysaccharidosis is a group of progressive metabolic disease (lysosomal storage) characterized by the deposition of glycosaminoglycans in the body, affecting various organs including the skeletal system, (dysostosis multiplex), viscera (hepatomegaly and splenomegaly), neurological complications, eyes (corneal opacity and optic atrophy), and cardiac (thickening and valvular heart disease). The disease can be classified into different types based on the specific enzymatic deficiency. In some types of this disease, treatment is administered weekly through enzyme replacement therapy. Due to the potential for severe reactions and even anaphylaxis during infusion, these medications are prescribed under medical supervision. This article presents a report of an 8-year-old girl diagnosed with Mucopolysaccharidosis type 1 was treated weekly with 2 vials of the enzyme Aldurazyme involving drug allergy to this medication along with a desensitization protocol. The protocol includes more premedication with prednisolone and the use of lower dilutions of the drug, lower infusion rate and gradually increasing the concentration and speed of the drug in addition to the routine administration of the enzyme.
Nasrin Moazzen; Fatemeh Shahrahmani; Yalda Ravanshad; anoush azarfar
Abstract
Background: Concern over male infertility has grown, with over half of infertility cases linked to male causes. The effect of radiofrequency electromagnetic radiation (RF-EMR) from mobile phones on sperm DNA fragmentation has been investigated. This mini-review evaluates literature on the correlation ...
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Background: Concern over male infertility has grown, with over half of infertility cases linked to male causes. The effect of radiofrequency electromagnetic radiation (RF-EMR) from mobile phones on sperm DNA fragmentation has been investigated. This mini-review evaluates literature on the correlation between RF-EMR and sperm DNA fragmentation.Methods: A systematic review was conducted using Google Scholar and PubMed databases up to July 2020. MeSH terms related to DNA fragmentation, sperm, mobile phones, radiofrequency, and related synonyms identified relevant studies. Nine studies were selected, and their methodologies examined.Results: The studies reviewed presented diverse findings on the correlation between RF-EMR from mobile phones and sperm DNA fragmentation. Of the nine investigations—five in vitro and four in vivo—all in vivo studies found significant DNA fragmentation in men who used their phones extensively, especially when carried in pants pockets. Three of the five in vitro tests showed a substantial effect, while the other two found no significant change between exposed and unexposed samples.Conclusion: Although more studies reported decreased sperm quality with prolonged and intense RF-EMR exposure, the evidence regarding DNA fragmentation remains inconclusive. With the widespread use of mobile phones, it is critical to further investigate their potential impact on male fertility and reproductive health. Existing evidence underscores the need for continued research in this area.