Maryam Dastfan; Ali Madadi Mahani; AmirAli Moodi Ghalibaf; Farid Poursadegh; Fariba Rezaeetalab; Ali Shamshirian; Mahnaz mozdorian
Abstract
Background:The Coronavirus disease 2019 (COVID-19) pandemic has posed significant challenges to healthcare systems worldwide. This cross-sectional study aimed to investigate the relationship between inflammatory markers, liver enzymes, lung involvement severity, and mortality in 841 COVID-19 patients ...
Read More
Background:The Coronavirus disease 2019 (COVID-19) pandemic has posed significant challenges to healthcare systems worldwide. This cross-sectional study aimed to investigate the relationship between inflammatory markers, liver enzymes, lung involvement severity, and mortality in 841 COVID-19 patients admitted to Imam Reza Hospital affiliated to the Mashhad University of Medical Sciences, Mashhad, Iran.Methods:The study included demographic information, physical and clinical symptoms, laboratory findings, computed tomography (CT) scan scores, and final outcomes. Results:The mean age of the patients was 58.23±16.44 years, and 39.2% were female. The most common underlying disease was hypertension (51.3%), and the most frequent symptom at presentation was shortness of breath (87.1%). The mortality rate was 33.8%. The results showed a significant direct correlation between CRP levels and LDH levels (r=0.129, p<0.001), as well as between CRP levels and CT scores (r=0.322, p<0.001). There was also a significant inverse correlation between CRP levels and patients' SPO2 (r=-0.309, p<0.001). ESR levels had no significant correlation with SPO2, LDH, AST, ALT, or CT scores. Expired patients had significantly lower SPO2 levels (p<0.001) and ALT (p=0.044), while CRP (p<0.001), LDH (p<0.001), and CT scores (p<0.001) were significantly higher compared to discharged patients.Conclusions:The findings suggest that serum CRP levels at admission can be used as a predictive factor for the severity of lung involvement and mortality in COVID-19 patients. Liver damage was also associated with worse clinical outcomes. ESR levels had no significant relationship with lung involvement severity and mortality, possibly due to the delay in ESR elevation in response to inflammation.
Reza Ibrahimi; Shadab Sahraian; AmirAli Moodi Ghalibaf; Mahnaz mozdorian
Abstract
Coronavirus disease 2019 (COVID-19) is a rapidly growing health concern claiming over 6 million lives as of April 2022. Some evidence revealed that pregnancy increases the risk of severe illness with Coronavirus infection. COVID-19 also complicates the pregnancy results such as the number of cesarean ...
Read More
Coronavirus disease 2019 (COVID-19) is a rapidly growing health concern claiming over 6 million lives as of April 2022. Some evidence revealed that pregnancy increases the risk of severe illness with Coronavirus infection. COVID-19 also complicates the pregnancy results such as the number of cesarean deliveries and premature births. Mitral stenosis is a structural heart disease that endangers the patient and their newborn, accompanied by serious morbidity and mortality. The present patient, 40 years old gravida 2 para 1 at 37 weeks presented to the emergency department with progressive dyspnea following fever and malaise for a week. SARS-CoV-2 testing was positive ergo appropriate treatment was administered. CT scan showed severe COVID-19 pneumonia with a severity index of 23. Due to respiratory distress, the patient was readily admitted to the intensive care unit. The patient was supported with non-invasive ventilation. Nevertheless, NIV was insufficient with signs of respiratory fatigue so the patient was intubated. Despite the subsidence of fever and stable clinical condition patient remained tachycardic which promoted us to perform echocardiography revealing severe mitral stenosis. This report contains our experience and suggestions regarding this rare concurrence. The paucity of data is significant regarding the management of concurrent structural heart disease and COVID-19 in pregnancy. It should be emphasized that the importance of maintaining routine care and screening during the pandemic; which can be catastrophic if missed.
Abolghasem Allahyari; Benyamin Hoseini; Mahnaz Mozdorian; Mohammad Khajedaluee; Mandana Khodashahi
Abstract
The potency of health systems to effectively respond to crises varies between high- and low-income countries. The COVID-19 pandemic has presented numerous challenges for hospitals worldwide. In this context, the resilience of health systems and the capacity of health institutions and populations play ...
Read More
The potency of health systems to effectively respond to crises varies between high- and low-income countries. The COVID-19 pandemic has presented numerous challenges for hospitals worldwide. In this context, the resilience of health systems and the capacity of health institutions and populations play a key role in mounting an effective response to crises.We gathered data on the condition and resilience of health systems in the two main hospitals in Mashhad, Iran, during three peaks of the COVID-19 pandemic. The results highlighted the fact that health systems officials and managers need to consider the consequences of COVID-19, such as the need for more beds and trained healthcare workers. Hospitals should take into account the impact of the COVID-19 pandemic across all wards and departments and prioritize the well-being of healthcare workers since they are at the forefront of the fight against this pandemic.
Fariba Rezaeetalab; Mahnaz Mozdourian
Abstract
Wilson’s disease is a rare genetic disorder, which is associated with clinical manifestations such as liver dysfunction, psychological and neurological issues, and specific laboratory findings demonstrating the increased urinary excretion of copper and copper accumulation in the body. Wilson’s ...
Read More
Wilson’s disease is a rare genetic disorder, which is associated with clinical manifestations such as liver dysfunction, psychological and neurological issues, and specific laboratory findings demonstrating the increased urinary excretion of copper and copper accumulation in the body. Wilson’s disease is occasionally presented by atypical features, which delay the diagnosis of this rare disorder. This study aimed to describe the case of a patient with pulmonary and portal hypertension as a primary manifestation of Wilson’s disease. A young male patient was admitted to the emergency department due to the deterioration of respiratory symptoms and overall weakness. The patient had a history of dyspnea and fatigue, which was diagnosed as idiopathic pulmonary hypertension. In the previous admission, the liver function test of the patient was not disrupted, and serum/urinary copper and ceruloplasmin levels were normal. In the current admission, the patient had elevated bilirubin and enzyme levels, as well as abnormal copper and ceruloplasmin levels. Moreover, portal hypertensive gastropathy and Kayser-Fleischer ring were detected in further investigations, confirming the diagnosis of Wilson’s disease. To the best of our knowledge, this was the first report on Wilson’s disease initially presented with pulmonary and portal hypertension.