Mohammad Reza Rouhbakhsh Zahmatkesh; Saman Soleimanpour; Zahra Mirfeizi; Nasrin Milani
Abstract
The coronavirus disease 2019 (COVID-19), which has spread to many countries, is so severe that it progresses rapidly to acute respiratory failure. Therefore, in our paper, we aimed to describe and evaluate the most practical laboratory pro-inflammatory factors to predict the course of severe COVID-19 ...
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The coronavirus disease 2019 (COVID-19), which has spread to many countries, is so severe that it progresses rapidly to acute respiratory failure. Therefore, in our paper, we aimed to describe and evaluate the most practical laboratory pro-inflammatory factors to predict the course of severe COVID-19 cases.Given the physiopathology of COVID-19 and the consequent immune system hyperactivity, we started to investigate the background pathology of these occurrences aiming to find the prognostic laboratory factors in COVID-19 cases. All reviews focused on the potential cellular and molecular mechanisms causing the cytokine storm in viral diseases, and several studies approved applicable laboratory parameters for COVID-19 patients. Based on our data, increased CRP level, LDH, serum ferritin, creatine kinase (CK), higher D-dimer and FDP levels, IL-6, cardiac troponin I and longer PT can be potential markers for predicting the course of infection; particularly, D-dimer, which was elevated to five times the original count in severe cases. Apart from that, the severe cases showed lymphopenia, neutrophilia, thrombocytopenia, and prolonged PTT. However, there was contradictory evidence about AST, ALT, BUN, and serum creatinine.The major cause of COVID-19 in critical patients was a cytokine storm; therefore, prognostic factors in the cytokine storm can also predict the prognosis of COVID-19. Thus, severe cases can be solved by early detection of these laboratory parameters.
Nasrin Milani; Mohamad Sajjadi-Manesh; Ehsan Mousa-Farkhani; Ali Taghipour
Abstract
Introduction: Hypertension (HTN) is one of the most life-threatening disorders worldwide. Although some examinations have demonstrated an incidental relationship between blood pressure and serum level of 25-hydroxyvitamin D, there have been new exchanges of views with respect to the influence of low ...
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Introduction: Hypertension (HTN) is one of the most life-threatening disorders worldwide. Although some examinations have demonstrated an incidental relationship between blood pressure and serum level of 25-hydroxyvitamin D, there have been new exchanges of views with respect to the influence of low vitamin D levels in hypertension. This study aims to find out the relationship between hypertension and regular consumption of vitamin D. Methods: A case-control study was conducted with regard to secondary data (SINA system) among people, aged 30 years old or older, registered in 2017-2018. A sample size of 1,500 patients was used comprising of 500 patients with hypertension as the case group and 1,000 people without history of hypertension as the control group. The population was selected randomly. High blood pressure diagnostic criteria were considered in the same manner with the clinical guidelines of the 7th National Joint Committee. Data were analyzed using SPSS 22 software.Results: Regular consumption of vitamin D had a protective role on hypertension (P value <0.05) and [OR= 0.421 (0.353- 0.505)].Conclusion: By identifying hypertension risk factors, taking measures to prevent it would be more practical and the risk of hypertension can be reduced. An enormous volume of epidemiological and empirical proof is indicative of the fact that vitamin D deficiency can lead to high blood pressure. The present investigation proves that vitamin D supplementary may serve as a convenient method to diminish the risk of progression of increased blood pressure due to its protective effect on blood pressure.
Kazem Saeedi; Ali Taghipour; Ehsan Mousa-Farkhani; Nasrin Milani
Abstract
Introduction: Diabetes is the most common metabolic disorder during pregnancy. Given the importance of the screening and treatment of gestational diabetes for the prevention of maternal and fetal complications, the present study aimed to evaluate the prevalence of gestational diabetes mellitus in the ...
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Introduction: Diabetes is the most common metabolic disorder during pregnancy. Given the importance of the screening and treatment of gestational diabetes for the prevention of maternal and fetal complications, the present study aimed to evaluate the prevalence of gestational diabetes mellitus in the pregnant women covered by Mashhad University of Medical Sciences, Iran.Methods: This study was conducted on the women with pregnancy intention or confirmed pregnancy, referring to the health centers affiliated to Mashhad University of Medical Sciences during March 2017-September 2018. The patients with gestational diabetes mellitus were identified based on the latest WHO criteria in 2013. Data were collected on the conducted experiments and recorded in the integrated health information system (SINA). Data analysis was performed in SPSS version 25 using Chi-square and logistic regression.Results: During the study period, 2,710 women (4.3%) were diagnosed gestational diabetes mellitus. The mean age of the patients was 28.5656.379 years. In terms of the influential factors, significant correlations were observed between gestational diabetes mellitus and family history of diabetes (OR=4.278; P<0.0001), history of gestational diabetes mellitus (OR=3.880; P<0.0001), body mass index (OR=2.302; P<0.0001), history of macrosomia (OR=1.656; P<0.003), history of recurrent miscarriage (OR=1.759; P<0.007), and preeclampsia (OR=1.914; P<0.045). Conclusion: According to the results, the prevalence of diabetes in Mashhad city (4.3%) seems to be slightly lower than other areas. Special attention must be paid to the pregnant women with the influential factors of gestational diabetes mellitus through selective screening based on the risk factors of the disease.