Kobra Salimiyan rizi; Hadi Farsiani
Abstract
The genus Raoultella is still understudied compared to other Enterobacteriaceae members. However, there are numerous published case reports on Raoultella infections. The genetic closeness of Raoultella spp. and Klebsiella spp. may lead to misidentification using conventional microbiology methods. The ...
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The genus Raoultella is still understudied compared to other Enterobacteriaceae members. However, there are numerous published case reports on Raoultella infections. The genetic closeness of Raoultella spp. and Klebsiella spp. may lead to misidentification using conventional microbiology methods. The prevalence of this bacterium in clinical settings can vary geographically. Our knowledge of its resistome evolution contributing to Raoultella antibiotic resistance is also limited to a few characterized genes. This review summarises the current knowledge on Raoultella genetic and microbiology aspects, its identification methods, virulence factors, clinical manifestations, and so on. This combined information highlights the gaps in our understanding of Raoultella pathogenesis, resistome, and vaccine suggesting future research directions. The diversity and plasticity of the antibiotic resistance plane of Raoultella species have determined the early and precise identification of Raoultella infection is very important to improve the prognosis of the clinical infections and to control the spread of this bacterium. According to our literature review results, patients with multiple congenital abnormalities are susceptible to Raoultella infection. Tumours, immune deficiency, and invasive operations increase the risk of infection.
Kobra Salimiyan rizi; Hadi Farsiani; Mohammad Momen Ghalibaf
Abstract
Today, human bloodstream infections (BSIs) are recognized as a major cause of morbidity and mortality worldwide. The bacteria, responsible for bacteremia, are usually identified in diagnostic clinical laboratories, using blood cultures. True bacteremia is defined as a positive blood culture (>15 CFU/mL), ...
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Today, human bloodstream infections (BSIs) are recognized as a major cause of morbidity and mortality worldwide. The bacteria, responsible for bacteremia, are usually identified in diagnostic clinical laboratories, using blood cultures. True bacteremia is defined as a positive blood culture (>15 CFU/mL), with signs and symptoms of infection (e.g., fever and chills). A wide range of bacteria can cause true bacteremia and some bacterial isolates from BSIs may be responsible for contamination. Gram-positive bacilli, such as Bacillus species, and coryneform bacteria are suspected sources of contamination in blood cultures. However, in certain patients, such as immunocompromised patients and intravenous drug users, gram-positive bacilli can act as a true pathogen. Therefore, it is important to know when gram positive bacilli act as a true pathogen and when they act as contamination. So, the rapidly diagnosis of true pathogens and appropriate treatment play a very important role in controlling infection with these bacteria. Effective measures are especially important in patients with an underlying disease or an immunocompromised status. In this article, we reviewed the literature on common Gram-positive rod-shaped bacteria, which were isolated from blood cultures and were suspected to be true pathogens or contaminants.