Zahra Ameri Golestan; Nasrin Moghadas Sharif; Nasser Shoeibi; Asieh Ehsaei; Alireza Eslampour; Maryam Kadkhoda; Javad Heravian Shandiz
Abstract
Introduction: This study aimed to investigate the effect of phacoemulsification on macular thickness and volume in diabetic patients without retinopathy using optical coherence tomography (OCT).Methods: This prospective study included 37 diabetics and 55 non-diabetic patients (n=92) with cataract who ...
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Introduction: This study aimed to investigate the effect of phacoemulsification on macular thickness and volume in diabetic patients without retinopathy using optical coherence tomography (OCT).Methods: This prospective study included 37 diabetics and 55 non-diabetic patients (n=92) with cataract who were scheduled for phacoemulsification. The participants were entered into the study based on the inclusion and exclusion criteria following a complete eye examination. Macular thickness and volume were measured preoperatively as well as one month postoperatively using the OCT (Spectralis; Heidelberg Engineering, Heidelberg, Germany).Results: The present study analyzed 76 eyes of 76 patients with immature cataract. No significant differences were observed between diabetic and non-diabetic groups in terms of thickness and volume in the macular area. However, the results showed a significant increase in both groups regarding the thickness and volume after phacoemulsification. Conclusion: The results of the present study reveal that diabetes has no effects on the changes in macular thickness and volume after cataract surgery in diabetic eyes without retinopathy.
Akbar Derakhshan; Alireza Eslampour; Esmaeil Safinezhad; Samira Hasanzadeh
Abstract
Introduction:Bevacizumab (Avastin), as an effectiveness treatment modality, is currently used in patients with various ocular disease. However the results have been promising, the use of bevacizumab in the treatment of ocular disease is an off-label application. Hence, the aim of this study was to systematically ...
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Introduction:Bevacizumab (Avastin), as an effectiveness treatment modality, is currently used in patients with various ocular disease. However the results have been promising, the use of bevacizumab in the treatment of ocular disease is an off-label application. Hence, the aim of this study was to systematically review the effectiveness of intravitreal injection of bevacizumab on various ocular tissues, especially corneal endothelial cells. Methods: The articles related to the effect of application of Avastin in the treatment of ophthalmic diseases and especially its effect on corneal endothelial cells were collected and reviewed. We searched PubMed, Google scholar, and Scopus databases and used Avastin, ocular diseases and corneal endothelial cells as search keywords.Result: Of all 55 articles found in all databases, only 10 were relevant to the purpose of this study, and 45 articles were excluded in several step by step process of article selection according to the inclusion/exclusion criteria. The results revealed that intracameral bevacizumab injection caused no changes in specular microscopy and corneal pachymetry. Moreover, it had no significant toxicity on corneal endothelial cells.Discussion: Effectiveness of bevacizumab as a new modality in the treatment of different ophthalmic diseases have been suggested. Recent data on both human and animal models showed that intravitreal injection of bevacizumab resulted in no significant toxicity on various ocular cells, and it could be considered as a suitable therapeutic approach in clinical use.Conclusion: According to the results of included documents, bevacizumab was not toxic to corneal endothelial cells at various clinically relevant doses.
Somayeh Tafaghodi Yousefi; Mohammad Etezad Razavi; Alireza Eslampour
Abstract
Amblyopia is one of the most important reversible eye disorders in children and different treatments are suggested. Early diagnosis and effective treatment in amblyogenic age are important criteria. These critical periods correspond to the period when the child’s developing visual system is sensitive ...
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Amblyopia is one of the most important reversible eye disorders in children and different treatments are suggested. Early diagnosis and effective treatment in amblyogenic age are important criteria. These critical periods correspond to the period when the child’s developing visual system is sensitive to abnormal input caused by stimulus deprivation, strabismus or significant refractive errors. Traditional treatments such as glass wearing, contact lens used with patch therapy have limitations. Laser corneal refractive surgeries introduce an alternative for the treatment of anisometropic amblyopia. Current indications for refractive surgery include anisometropia, bilateral high myopia and accommodative esotropia. Several reports confirmed that with recent development in keratorefractive surgery, it could be a safe method to be used in children. The goal of the permanent surgical treatment is to reduce refractive errors, treat amblyopia and make better the binocular function. Corneal haze is certainly a major concern in children receiving surface ablation, especially in high myopic treatments. However, controversies still exist on whether it could be done in this population or not. This article reviews the available data about refractive surgery for treating anisometropic amblyopia.