Mina Erfani; Farah Ashrafzadeh; javad Akhondian; Hamid Reza Rahimi; Mehran Beiraghi-Toosi; Hashem Lashgari-Kalat; Ehsan Alaei; Monica Zeynalzadeh
Abstract
Nearly 70 million people worldwide suffer from epilepsy. Despite administration of routine antiepileptic drugs (AEDs), nearly 30% of seizures are resistant to treatment called drug resistant epilepsy (DRE). Since the epilepsy treatment may result in consequences of multi-drugs administration or sometimes ...
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Nearly 70 million people worldwide suffer from epilepsy. Despite administration of routine antiepileptic drugs (AEDs), nearly 30% of seizures are resistant to treatment called drug resistant epilepsy (DRE). Since the epilepsy treatment may result in consequences of multi-drugs administration or sometimes invasive surgical methods in DRE, herbal treatment can be a good alternative choice due to its easy accessibility, lower cost and fewer side effects. Although turmeric has been one of a very commonly used dietary spices and traditional herbal remedies, its derivation as a newly introduced medicine-curcumin has not been used to a large extent. In this literature, we have reviewed the available trial researches, which studied specifically antiepileptic effect of curcumin. We searched databases of Science direct, PubMed and Google Scholar (2008 to 2016) with key words of turmeric, curcumin, Diferuloylmethane, Epilepsy, and Seizure to find the related references. The major extract of turmeric curcumin has found to have antiepileptic effect according to recent surveys. It not only has no critical adverse effect, but also can protect patients from other AEDs severe side effects. It also makes it possible to gradually decrease the dose of AEDs in long-term combination therapy.
Vahid Shojaee; Mostafa Dastani; Alireza Abdolahi; Hamid Reza Rahimi
Abstract
Cerebrovascular event is one of the important causes of death in the world. Carotid artery stenosis is one of main risk factors of cerebrovascular events. Risk factors for atherosclerosis are found in carotid artery stenosis. Thus, coincidence of coronary artery disease and carotid artery stenosis were ...
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Cerebrovascular event is one of the important causes of death in the world. Carotid artery stenosis is one of main risk factors of cerebrovascular events. Risk factors for atherosclerosis are found in carotid artery stenosis. Thus, coincidence of coronary artery disease and carotid artery stenosis were observed. In an individual with high risk of coronary artery plaque formation, peripheral artery stenosis is imaginable. Histological morphology and plaque formation in coronary artery disease and carotid artery stenosis are similar and they occur together most of the time. Although many similar findings were shown in coronary artery disease and carotid artery stenosis, carotid artery stenosis is associated with more severe stenosis compare with coronary artery disease. Carotid artery stenosis does not have exact similar biological activity with coronary artery disease.Some invasive and non-invasive diagnostic methods are established for carotid artery stenosis detection.Same medical and surgical treatment techniques could be used for carotid artery stenosis management that vary due to patient-to-patient specific conditions.
Reza Ghasemi; Mostafa Dastani; Alireza Abdolahi; Hamid Reza Rahimi
Abstract
Atherosclerosis is a chronic slow-developing condition affecting medium-size and large blood vessels. It is the principal underlying pathology of coronary heart disease and stroke. In some countries, coronary artery disease (CAD) is the cause of nearly half (48%) of the deaths and, loss of productivity ...
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Atherosclerosis is a chronic slow-developing condition affecting medium-size and large blood vessels. It is the principal underlying pathology of coronary heart disease and stroke. In some countries, coronary artery disease (CAD) is the cause of nearly half (48%) of the deaths and, loss of productivity life. Peripheral arterial disease (PAD) is defined as atherosclerosis in peripheral arteries instead of coronary arteries. CAD and PAD have same risk factors and underlying pathophysiological processes. Therefore, patient with CAD should be considered for PAD. Ankle brachial index (ABI), duplex sonography, and some other non-invasive techniques are recommended for PAD diagnosis in patients with the history of CAD. Pharmacotherapy, endovascular interventions, and surgical management could be chosen according to the patient’s situation. Cardiologists and general practitioners should consider PAD in a patient with CAD or DM as a strong correlated disease.
Mahmoud Ebrahimi; Azamat Sabouri Arteh; Hamid Reza Rahimi
Abstract
Coronary artery disease (CAD) is a major global problem. In addition, it is higher risk of mortality for women more than men are when develop in female gender Atherosclerotic plaques consist of deposits of fatty material in the tunica intima. The role of inflammatory process in CAD has been known from ...
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Coronary artery disease (CAD) is a major global problem. In addition, it is higher risk of mortality for women more than men are when develop in female gender Atherosclerotic plaques consist of deposits of fatty material in the tunica intima. The role of inflammatory process in CAD has been known from 1980’s. Several studies investigated the innate immunity and adaptive immunity roles in atherosclerosis and they concluded that it plays a key role in atherosclerosis. Coronary artery bypass grafting (CABG) is a widely used method for the treatment of CAD. Based on the literature, CABG is the most common surgical operation done worldwide. In During the first 10 years after CABG, up to 50% of saphenous grafts will occlude. Graft restenosis is beginning with acute thrombosis, intima hyperplasia, and plaque formation. In this review, some molecular pathways of graft failure and restenosis such as apoptosis and nuclear factor kappa B (NF-ĸB) are described.