Maryam Dastfan; Ali Madadi Mahani; AmirAli Moodi Ghalibaf; Farid Poursadegh; Fariba Rezaeetalab; Ali Shamshirian; Mahnaz mozdorian
Abstract
Background:The Coronavirus disease 2019 (COVID-19) pandemic has posed significant challenges to healthcare systems worldwide. This cross-sectional study aimed to investigate the relationship between inflammatory markers, liver enzymes, lung involvement severity, and mortality in 841 COVID-19 patients ...
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Background:The Coronavirus disease 2019 (COVID-19) pandemic has posed significant challenges to healthcare systems worldwide. This cross-sectional study aimed to investigate the relationship between inflammatory markers, liver enzymes, lung involvement severity, and mortality in 841 COVID-19 patients admitted to Imam Reza Hospital affiliated to the Mashhad University of Medical Sciences, Mashhad, Iran.Methods:The study included demographic information, physical and clinical symptoms, laboratory findings, computed tomography (CT) scan scores, and final outcomes. Results:The mean age of the patients was 58.23±16.44 years, and 39.2% were female. The most common underlying disease was hypertension (51.3%), and the most frequent symptom at presentation was shortness of breath (87.1%). The mortality rate was 33.8%. The results showed a significant direct correlation between CRP levels and LDH levels (r=0.129, p<0.001), as well as between CRP levels and CT scores (r=0.322, p<0.001). There was also a significant inverse correlation between CRP levels and patients' SPO2 (r=-0.309, p<0.001). ESR levels had no significant correlation with SPO2, LDH, AST, ALT, or CT scores. Expired patients had significantly lower SPO2 levels (p<0.001) and ALT (p=0.044), while CRP (p<0.001), LDH (p<0.001), and CT scores (p<0.001) were significantly higher compared to discharged patients.Conclusions:The findings suggest that serum CRP levels at admission can be used as a predictive factor for the severity of lung involvement and mortality in COVID-19 patients. Liver damage was also associated with worse clinical outcomes. ESR levels had no significant relationship with lung involvement severity and mortality, possibly due to the delay in ESR elevation in response to inflammation.
Hamideh Ebrahimi Gore; Ali Taghizadeh; AmirAli Moodi Ghalibaf; Ali Shamshirian; Mohammad Reza Motie
Abstract
Introduction: The breast cancer burden is still increasing, both in developing and developed countries. The present study was conducted to determine the survival rate of breast cancer based on tumor biological subtypes in patients referring to three referral oncology centers at Mashhad University of ...
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Introduction: The breast cancer burden is still increasing, both in developing and developed countries. The present study was conducted to determine the survival rate of breast cancer based on tumor biological subtypes in patients referring to three referral oncology centers at Mashhad University of Medical Sciences, Mashhad, Iran.Methods: The present population-based study was conducted at Imam Reza Hospital, Omid Hospital, and Reza Oncology Center, Mashhad University of Medical Sciences, Mashhad, Iran Demographic information, the status of biomarkers in immune-histochemical evaluation, clinical and pathological features of the tumor, type of therapy, recurrence, or death was recorded for each eligible patient.Results: In total, 247 patients were included in the study. The mean age of patients was 48.8 ± 1.3 years. The mean time of survival was 2.64±0.13 years. In detail, the survival rate from the first year to the fifth year was reported as 100%, 96%, 91%, 90%, and 89%, respectively. The survival rate of the luminal B subtype was higher than other subtypes but the difference was not significant (P=0.7). Only in terms of metastasis, there was a significant difference between the alive and dead patients (P=0.0001).Conclusion: Despite no significant relationship between biological markers, the breast cancer subtype, and its survival rate, the overall survival rate of the patients decreased lightly through five years. However, further studies are required to indicate more accurate data about the breast cancer survival rate in our region.