Nahid Maleki; Elahe Akbari; Hamid Heidarian; Sanam Borji
Abstract
Background:Premenstrual disorder (PMS) is perhaps the most widely recognized issues among women of reproductive age. The utilization of natural therapies or complementary medicine has grown in recent years, especially among women. PurposeThis study aimed to determine the efficacy of saffron on the treatment ...
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Background:Premenstrual disorder (PMS) is perhaps the most widely recognized issues among women of reproductive age. The utilization of natural therapies or complementary medicine has grown in recent years, especially among women. PurposeThis study aimed to determine the efficacy of saffron on the treatment of PMS. MethodElectronic searching of Medline, PubMed, Scopus, Cochrane, Embase, Web of science, SID and Google Scholar was performed up to Jan 2024. Inclusion criteria consist of both English and Persian, published, clinical trials using saffron as medical for treatment of PMS. In the long run Five CTs met the inclusion criteria. The quality of these trials was evaluated by two researchers who carried out the data extraction, using Oxford Center for Evidence Based Medicine checklist. A total of three RCTs were ultimately included in a meta-analysis. Statistical analysis were performed by Comprehensive Meta-analysis (CMA) Version 2.ResultsQualitative analysis revealed that 8-12 week of treatment with saffron could be effective in reducing the symptoms and severity of PMS and it might cause fewer side effects than chemical medicines. Three studies were included in the quantitative analysis, which resulted in a mean difference of 0.63 with 95% confidence interval (CI) (1.18-0.07), implying that the effects of saffron on PMS were statistically significant (p=0.03).ConclusionAlthough saffron has a positive effect on PMS but interpretation of results is limited because of methodological flaws of the included studies so further trials are still needed to confirm the current findings.
Morvarid Irani; Ali Saberi; Zahra shojaeian; Mohamad Ghorbani; Nahid Maleki
Abstract
Background: Uterine fibroids or Leiomyoma (UFs) are one of a common problem that affects the quality of life in women. Recently use of vitamin D for treating Leiomyoma has been considered. Study's PurposeThis Systematic Review was performed with aim to evaluate the current evidence for the efficacy of ...
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Background: Uterine fibroids or Leiomyoma (UFs) are one of a common problem that affects the quality of life in women. Recently use of vitamin D for treating Leiomyoma has been considered. Study's PurposeThis Systematic Review was performed with aim to evaluate the current evidence for the efficacy of vitamin D in treating uterine fibroids.Methods: Relevant studies were identified from the following Electronic searching of Medline, PubMed, Scopus, Cochrane, Embase, Web of science, SID and Google Scholar up to Feb 2021. Inclusion criteria consist of Both English and Persian, published, clinical trials using vitamin D as medical for treatment of uterine fibroids. In the long run four RCTs met the inclusion criteria. The quality of these trials was evaluated by two researchers who carried out the data extraction, using Oxford Center for Evidence Based Medicine checklist. Statistical analysis was performed by Comprehensive Meta-analysis (CMA) Version 2. To assess the publication bias and heterogeneity, Egger’s and Begg’s tests and I2 were used, respectively. In addition, the Random effects model was employed to perform the meta-analysis. Findings: The heterogeneity in the studies was determined as 95.17% (p<0.000). There was publication bias among the studies included; the p-values of Egger’s and Begg’s tests were 0.05 and 0.05, respectively. The effects of Vit D on UFs was statistically significant [mean difference (MD) =2.88; 95% confidence interval (CI): (4.72-1.044); p<0.002]. Conclusion: Vitamin D for treating uterine fibroids can be an effective method, but more studies are needed to confirm these findings.