Koosha Rokhzadi; Mohammad Bakhtiar Hesam Shariati; Kaveh Haji-Allahverdipoor; Susan Mohammadi
Abstract
Hydatid cyst, a common ailment affecting both humans and animals, has the potential to develop in various anatomical locations, with the liver and lungs being the primary sites of occurrence. Individuals in endemic regions, particularly those involved in livestock farming, face an increased risk of exposure ...
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Hydatid cyst, a common ailment affecting both humans and animals, has the potential to develop in various anatomical locations, with the liver and lungs being the primary sites of occurrence. Individuals in endemic regions, particularly those involved in livestock farming, face an increased risk of exposure to this parasitic disease. The cysts can concurrently manifest in multiple areas of the body, highlighting the intricate nature of their presentation. Despite often being asymptomatic, early detection of hydatid cysts is crucial for effective intervention. Diagnostic tools such as ultrasound, CT scans, and serological tests play a pivotal role in identifying these cysts, even without overt symptoms. The insidious progression of hydatid cysts allows them to persist asymptomatically over prolonged periods, posing a latent threat. However, the rupture of these cysts, whether spontaneous or triggered by external factors, can result in severe consequences, potentially leading to fatality. This study reports a compelling case involving a 41-year-old woman investigating the causes of infertility. Through comprehensive examinations, multiple hydatid cysts were serendipitously discovered in her liver, spleen, and kidneys. This case underscores the diverse anatomical locations these cysts can occupy and emphasizes the significance of vigilant diagnostic approaches, even in individuals initially presenting with unrelated concerns such as infertility.
Afshan Shirkavand; Zahra Razaghi; Sharam Akhlaghpoor; Azita Azarkeivan; Mehran Karimi
Abstract
Introduction: Multi-organ iron load is prevalent crucial side effect in thalassemic patients due to repeated transfusions, and high intestinal iron absorption. MRI T2* has demonstrated its potency as a non-invasive technique for the imaging of hemosiderosis in thalassemia. We aim to investigate the iron ...
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Introduction: Multi-organ iron load is prevalent crucial side effect in thalassemic patients due to repeated transfusions, and high intestinal iron absorption. MRI T2* has demonstrated its potency as a non-invasive technique for the imaging of hemosiderosis in thalassemia. We aim to investigate the iron load of adrenal glands and kidneys using MRI T2* in adult thalassemia patients and evaluate the serum ferritin correlation of with kidneys, heart, liver, and adrenal glands’ iron load.Methods: Thirty-five thalassemia major (TM) and thalassemia intermediate (TI) patients (age range 18-50 years) from Zafar thalassemia Clinic, were recruited in this survey from September 2019 to October 2020. Magnetic Resonance Imaging (MRI) was used to map iron overload in several organs’ regions of interest (ROIs) using fast-gradient-echo multi echo T2*sequences protocol. T-test and chi-square analysis were done.Results: Nine (25.7%) patients had left Kidney T2* less than 36ms which could indicate abnormal renal iron load while this was 8 (22.9%) for the right kidney. In the left and right adrenal glands, these numbers were 31 (88.6%) and 29 (82.9%), respectively, below the normal threshold.Conclusion: Adrenal gland and renal iron overloads were detected in MRI images of thalassemic patients. Correlation for serum ferritin levels and kidney and adrenal glands T2* was found weakly negative. Non-invasive monitoring of the internal organs’ hemosiderosis using MRI T2* was found to be beneficial for iron-chelating optimization and preventing irreversible tissue damage.
Sara Hashemi
Abstract
Cyclooxygenase 2 has become an important pharmacological target in anticancer therapy due to the over expression of COX 2 in pathological conditions. Wilms’ tumor is a common kidney cancer in children which has shown an increase in COX 2 enzyme level. Here we reviewed various articles that considered ...
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Cyclooxygenase 2 has become an important pharmacological target in anticancer therapy due to the over expression of COX 2 in pathological conditions. Wilms’ tumor is a common kidney cancer in children which has shown an increase in COX 2 enzyme level. Here we reviewed various articles that considered the cyclooxygenase 2 changes specifically in Wilms’ tumor regarding the mechanisms of action and inhibitors of COX 2.