Forough Rakhshanizadeh; Farhad Heydarian; Elahe Heidari; Lida Jarahi; hassan kani
Abstract
Objective: An imbalance has been reported in the oxidant-antioxidant system of infants with febrile convulsion. This study aimed to compare serum vitamin C levels between febrile children with or without seizures. Materials and Method: This multicenter case-control study was conducted on febrile infants ...
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Objective: An imbalance has been reported in the oxidant-antioxidant system of infants with febrile convulsion. This study aimed to compare serum vitamin C levels between febrile children with or without seizures. Materials and Method: This multicenter case-control study was conducted on febrile infants and children who were referred to the pediatric emergency wards of Mashhad University of Medical Science. The subjects were equally divided into two febrile groups of case (with seizure) and control (without seizures). Visible Spectrophotometer was used to determine the total vitamin C level.Results: In total, 100 febrile children were included in this study. Based on the results, there was no statistically significant difference between the two groups in terms of age, gender, and family history of febrile convulsion (FC) (P>0.05). The mean vitamin C levels in the case and control groups were 42.73±7.2 and 78.59±11.1 µg/l, respectively. There was a significant difference between the groups regarding the vitamin C level (P<0.001). Regression analysis revealed that age (P=0.74), gender (P=0.66), and family history of febrile convulsion (P=0.52) had not any correlation with vitamin C levels. On the other hand, the vitamin C levels was associated with FC (P=0.001).Conclusion: The serum levels of vitamin C in the children with febrile seizure were lower than those in the control group. Thus, the reduced vitamin C levels can be considered as a predisposing factor for FC.
Soheila Pourmasumi; Parvin Sabeti
Abstract
Oxidative stress is an imbalance between the level of ROS and antioxidants. Sperm membranes are rich in polyunsaturated fatty acids and are very sensitive to increased free radicals. Increasing the level of ROS can lead to an increase in lipid peroxidation in sperm membrane, decrease in their flexibility, ...
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Oxidative stress is an imbalance between the level of ROS and antioxidants. Sperm membranes are rich in polyunsaturated fatty acids and are very sensitive to increased free radicals. Increasing the level of ROS can lead to an increase in lipid peroxidation in sperm membrane, decrease in their flexibility, and ultimately a decrease in sperm motility. Also, oxidative stress may impair sperm axonemal and mitochondrial function, as well as DNA integrity, RNA and protein synthesis. Several studies have shown that antioxidants are beneficial to human health and are used to prevent cancer and coronary artery disease. Based on the present review, there are more documents in protective effects of antioxidants on sperm cells. Studies showed adding in vitro antioxidants to sperm samples can increase sperm parameters such as sperm motility, morphology and decrease sperm membrane lipid peroxidation and sperm DNA damage. Also in vivo or oral antioxidants supplementation has protective effects on sperm from ROS negative effects. Since the causes of infertility are various, the lack of antioxidants action in reducing the sperm DNA damage, the level of antioxidant activity depends on the type, dose and duration of intake, so more studies are needed to determine the appropriate antioxidant type, the dosage and timing of administration in vivo and in vitro.
Mostafa Delshad; Azita Fesharakinia; Samaneh Eghbal
Abstract
Introduction: Urinary tract infection (UTI) that can affect any part of the urinary tract and may subsequently lead to kidney infection is linked with variety of causative factors such as oxidative stress. In this study, we aimed to systematically review the literatures to evaluate the effects of oxidative ...
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Introduction: Urinary tract infection (UTI) that can affect any part of the urinary tract and may subsequently lead to kidney infection is linked with variety of causative factors such as oxidative stress. In this study, we aimed to systematically review the literatures to evaluate the effects of oxidative stress on UTI. Method: PubMed and Google scholar were searched systematically using the key terms, “oxidative stress” and “urinary tract infection” in the title, keywords, and abstract on February 2015 to find articles in which the oxidative stresses had been evaluated in children with urinary tract infection (UTI). Papers were excluded if they were unrelated to the purpose of this study, or in language other than English. Full texts of the relevant documents were fully reviewed for data extraction.Result: Of overall 50 articles from PubMed, and 6 records found in Google scholar, only 8 articles met the inclusion criteria for further assessment. Additionally, three papers were omitted due to full texts unavailability or language irrelevancy, and five articles, which fully met the inclusion criteria, were used for data extraction. The results showed that the level of antioxidant decreases significantly in patients with UTI, while the markers of oxidative stress increases.Conclusions: The results of the studies showed that the level of antioxidants decreases in patients with UTI, while lipid peroxidase and the level of oxidative stress biomarkers such as malondialdehyde and reactive oxygen species increase. These findings are suggestive of an association between oxidative stress and UTI. The role of oxidative stress in pediatric urinary tract infections: a systematic review