Asal Yadollahi; Mostafa dastani; Bita Zargaran; Amir hossein Ghasemi; Hamid reza Rahimi
Abstract
Curcumin (diferuloylmethane) is a yellow, active substance of an herbal origin, which is mainly derived from turmeric of the ginger family. Extensive research has been focused on the therapeutic effects of this substance on diabetes, cancer, and cardiovascular diseases, and the hepatoprotective properties ...
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Curcumin (diferuloylmethane) is a yellow, active substance of an herbal origin, which is mainly derived from turmeric of the ginger family. Extensive research has been focused on the therapeutic effects of this substance on diabetes, cancer, and cardiovascular diseases, and the hepatoprotective properties have attracted the attention of researchers. In addition, curcumin significantly improves oxidative stress, mitochondrial dysfunction, and inflammation. It could also modulate various cell signals in cytokines, chemokines, growth factors, and enzymes. Curcumin attenuates the blood glucose by increasing insulin levels. According to findings, consuming one gram of curcumin per day for one month could decrease total cholesterol, low-density lipoprotein cholesterol, triglyceride, and high-density lipoprotein cholesterol. Moreover, it contributes to the control of some of the main parameters associated with the metabolic syndrome, which is an important risk factor for cardiovascular diseases. Hepatic cholesterol metabolism is also regulated by curcumin, which has a similar function to lovastatin in the long run. Curcumin has been reported to prevent the enlargement of solid tumours. Several have confirmed the therapeutic role of curcumin in the management of the metabolic syndromes and cardiovascular diseases. The present study aimed to review the therapeutic effects of curcumin.
Mina Erfani; Farah Ashrafzadeh; javad Akhondian; Hamid Reza Rahimi; Mehran Beiraghi-Toosi; Hashem Lashgari-Kalat; Ehsan Alaei; Monica Zeynalzadeh
Abstract
Nearly 70 million people worldwide suffer from epilepsy. Despite administration of routine antiepileptic drugs (AEDs), nearly 30% of seizures are resistant to treatment called drug resistant epilepsy (DRE). Since the epilepsy treatment may result in consequences of multi-drugs administration or sometimes ...
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Nearly 70 million people worldwide suffer from epilepsy. Despite administration of routine antiepileptic drugs (AEDs), nearly 30% of seizures are resistant to treatment called drug resistant epilepsy (DRE). Since the epilepsy treatment may result in consequences of multi-drugs administration or sometimes invasive surgical methods in DRE, herbal treatment can be a good alternative choice due to its easy accessibility, lower cost and fewer side effects. Although turmeric has been one of a very commonly used dietary spices and traditional herbal remedies, its derivation as a newly introduced medicine-curcumin has not been used to a large extent. In this literature, we have reviewed the available trial researches, which studied specifically antiepileptic effect of curcumin. We searched databases of Science direct, PubMed and Google Scholar (2008 to 2016) with key words of turmeric, curcumin, Diferuloylmethane, Epilepsy, and Seizure to find the related references. The major extract of turmeric curcumin has found to have antiepileptic effect according to recent surveys. It not only has no critical adverse effect, but also can protect patients from other AEDs severe side effects. It also makes it possible to gradually decrease the dose of AEDs in long-term combination therapy.