Morvarid Irani; Ali Saberi; Zahra shojaeian; Mohamad Ghorbani; Nahid Maleki
Abstract
Background: Uterine fibroids or Leiomyoma (UFs) are one of a common problem that affects the quality of life in women. Recently use of vitamin D for treating Leiomyoma has been considered. Study's PurposeThis Systematic Review was performed with aim to evaluate the current evidence for the efficacy of ...
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Background: Uterine fibroids or Leiomyoma (UFs) are one of a common problem that affects the quality of life in women. Recently use of vitamin D for treating Leiomyoma has been considered. Study's PurposeThis Systematic Review was performed with aim to evaluate the current evidence for the efficacy of vitamin D in treating uterine fibroids.Methods: Relevant studies were identified from the following Electronic searching of Medline, PubMed, Scopus, Cochrane, Embase, Web of science, SID and Google Scholar up to Feb 2021. Inclusion criteria consist of Both English and Persian, published, clinical trials using vitamin D as medical for treatment of uterine fibroids. In the long run four RCTs met the inclusion criteria. The quality of these trials was evaluated by two researchers who carried out the data extraction, using Oxford Center for Evidence Based Medicine checklist. Statistical analysis was performed by Comprehensive Meta-analysis (CMA) Version 2. To assess the publication bias and heterogeneity, Egger’s and Begg’s tests and I2 were used, respectively. In addition, the Random effects model was employed to perform the meta-analysis. Findings: The heterogeneity in the studies was determined as 95.17% (p<0.000). There was publication bias among the studies included; the p-values of Egger’s and Begg’s tests were 0.05 and 0.05, respectively. The effects of Vit D on UFs was statistically significant [mean difference (MD) =2.88; 95% confidence interval (CI): (4.72-1.044); p<0.002]. Conclusion: Vitamin D for treating uterine fibroids can be an effective method, but more studies are needed to confirm these findings.
Afsaneh Bahrami; Elahe Allahyari; Afrooz Arzehgar; Mehdi Sohrabi; Elham Amirzadeh; Soheila Alipour; Gordon A. Ferns; majid Ghayour
Abstract
Introduction: The serum 25(OH)D response to vitamin D supplementation, differs between individuals. The goal of this study was the evaluation of the relationship between socioeconomic and demographic factors with the hugeness of response to vitamin supplementation, defined by statistical ...
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Introduction: The serum 25(OH)D response to vitamin D supplementation, differs between individuals. The goal of this study was the evaluation of the relationship between socioeconomic and demographic factors with the hugeness of response to vitamin supplementation, defined by statistical analysis artificial neural network (ANNs).
Methods: The prospective interventional study was conducted on 529 participants aged 19-12 years old. All participants were administrated to receive nine vitamin D capsules (50000IU vitamin D) over nine weeks. The response variables were the following: the differences between the concentrations of vitamin D before and after intervention.
Results: Among various sociodemographic factors which affect the increase in serum vitamin D amounts in response to supplementations, baseline serum vitamin D (%28.1), BMI (%13.8), physical activity (%12.1), age (%7.6), mother›s education (%6.4), and father›s occupation (%5.8) be important variables.
Conclusion: This interventional study provides specific sociodemographicrecommendations to achieve 25(OH)D targets in cases with severe vitamin D deficiency, perhaps indicating that a higher dose is require to obtain optimal Vit D levels in some individuals.