Hesaneh Izadyar; Mitra Ahadi; Ahmad Khosravi Khorashad; Hassan Saadatnia; Hasan Vosoghinia; Mohamadreza Farzanehfar; Ali Beheshti Namdar; Elham Mokhtari Amirmajdi; Sahar Khorasani; Hamid Reza Akbari; Foad Faroughi Bojd
Abstract
Introduction: The present study was conducted to evaluate the prevalence of trend and use of complementary and alternative medicine in patients referring to the Gastroenterology clinics in Mashhad. Methods: The present cross-sectional study was performed at Gastroenterology clinics affiliated with ...
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Introduction: The present study was conducted to evaluate the prevalence of trend and use of complementary and alternative medicine in patients referring to the Gastroenterology clinics in Mashhad. Methods: The present cross-sectional study was performed at Gastroenterology clinics affiliated with Mashhad University of Medical Sciences. The study began in December 2015 and ended in March 2017. The study subjects (n=751) were randomly selected from patients referring to Gastroenterology clinics in the city of Mashhad. Patients responded to the questions through interviews. The collected data were analyzed by SPSS-16 statistical software.Results: This study was conducted on 751 patients referring to gastroenterologists; of whom, 274 (48.36%) were male and 476 (38.63) were female. According to the results, the most popular complementary and alternative medicine treatments were respectively herbal medicine, cupping therapy and acupuncture. A significant difference was observed in the means at is faction with complementary and alternative medicine between those who believed in it and those who did not (p=0.001); but, no significant difference was detected in mean satisfaction with complementary and alternative medicine between patients with different occupations (p=0.193). There was also a significant difference in the number of patients between the group of patients receiving chemical medication and the group of patients receiving complementary and alternative medicine therapies (p=0.005). No significant difference was found in the level of satisfaction with complementary and alternative medicine between participants referring to the Gastroenterology clinics for different causes (p=0.431); nonetheless, the highest satisfaction was observed in patients with malignancy, and the lowest satisfaction was detected in patients with esophageal disorders.Conclusion: This study indicated the high prevalence of complementary and alternative medicine in Iran. The worldwide popularity of complementary and alternative medicine should not be overlooked, therefore; current medical treatment systems need to be revised and modified
Zahra Ahmadi; Sahar Roomiani; Niloofar Bemani; Milad Ashrafizadeh
Abstract
In recent decades, special attention has been paid to cell death mechanisms, with the exception of apoptosis. This could be due to the resistance of cells, particularly cancer cells, to apoptosis. Among novel pathways, autophagy and endoplasmic reticulum (ER) stress have attracted the attention of researchers. ...
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In recent decades, special attention has been paid to cell death mechanisms, with the exception of apoptosis. This could be due to the resistance of cells, particularly cancer cells, to apoptosis. Among novel pathways, autophagy and endoplasmic reticulum (ER) stress have attracted the attention of researchers. A large number of antitumor drugs have been developed based on their modulatory effects on autophagy and ER stress. On the other hand, ER stress could stimulate autophagy and apoptosis, which is indicative of the dual role of this pathway. Therefore, the monitoring of these pathways could contribute to the treatment of pathological conditions. Among the multiple synthetic and natural modulators of autophagy and ER stress, natural agents are used more extensively owing to their few side-effects, valuable biological activities, and cost-efficiency. Honokiol as a lignin extracted from the bark of magnolia tree. This compound has been reported to have antioxidant, anti-inflammatory, anti-diabetic, and antitumor effects. The present study aimed to first introduce honokiol, autophagy, and ER stress and assess the modulatory effects of honokiol on the autophagy and ER stress mechanisms so as to demonstrate the therapeutic efficacy of this natural compound.
Aliasghar Moeinipour; Mohamad Abbassi Teshnizi; Babak Manafi; Hadi Yavari; Yasamin Moeinipour; Hamid Hoseinikhah
Abstract
Herbal medicine is usually safe and popular in Iranian communities. Peppermint herbal products may interact with warfarin, which is an essential lifelong drug used in patients with prosthetic heart valves. Herein, we report a case of possible interaction between warfarin and peppermint herbal tea.We ...
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Herbal medicine is usually safe and popular in Iranian communities. Peppermint herbal products may interact with warfarin, which is an essential lifelong drug used in patients with prosthetic heart valves. Herein, we report a case of possible interaction between warfarin and peppermint herbal tea.We described a 68-year-old woman who was on warfarin treatment due to bileaflet mechanical aortic valve, and mitral valve replacement presented with severe dyspnea in the setting of large obstructive prosthetic mitral valve thrombosis diagnosed by echocardiography. Therefore, cardiac surgery was conducted in the emergent setting. Warfarin was started the day after the procedure. She developed melena with a volatile and elevated international normalized ratio (INR) of 4.8 and prothrombin time > 30 s on the 7th post-operation day. She reported no changes in drug or dietary habits except for drinking high amounts of peppermint tea the day before. After the discontinuation of warfarin and medical consultation for gastrointestinal bleeding, the INR level decreased to 1.8 within two days.Consumption of peppermint herbal products are usually safe; however, caution should be taken with patients under warfarin treatment. Full disclosure for patients on anticoagulant treatment is necessary before discharge and during clinical follow-up
Zohre Seidi
Abstract
Leishmaniasis including Cutaneous, mocucutaneous and Visceral forms of clinical syndromes is one of the important health care problem in the world specially in developing countries. Because of long time duration of treatment, being expensive, many associated side effects and eventually resisted cases ...
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Leishmaniasis including Cutaneous, mocucutaneous and Visceral forms of clinical syndromes is one of the important health care problem in the world specially in developing countries. Because of long time duration of treatment, being expensive, many associated side effects and eventually resisted cases to conventional therapy, enormous efforts have been performed to replace herbal and new therapeutic strategies as alternative choices.This review argue about reported studies have conducted by many researchers around the world since 1990 that the subject of all of them were about herbal medicine in treatment of leishmaniasis with emphasis on cutaneous leishmaniasis.