Hamidreza Kianifar; Saeedeh Talebi
Abstract
Introduction: Epidermolysis bullosa is a genetic condition with skin fragility that leads to blister formation and erosion following minor trauma. This disease also involves the gastrointestinal tract by way of esophageal stricture and dysphasia. Some studies have recommended oral budesonide liquid therapy ...
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Introduction: Epidermolysis bullosa is a genetic condition with skin fragility that leads to blister formation and erosion following minor trauma. This disease also involves the gastrointestinal tract by way of esophageal stricture and dysphasia. Some studies have recommended oral budesonide liquid therapy to decrease the need for balloon endoscopy and other aggressive treatments. The aim of the study was to evaluated clinical symptoms of patients who consumed oral budesonide in their daily routine therapies.
Methods: This cross-sectional study was conducted in Akbar Hospital of the Mashhad University of Medical Sciences. All enrolled patients were followed between July and October 2021. Ten milliliter oral budesonide (0.5 milligram) liquid was administrated one hour before eating. They were followed up to determine and document any side effects after treatment, and any improvement of clinical symptoms such as amelioration of dysphasia, volume of food intake, duration of food consumption, and kind of food consumed (solid versus liquid).Results: About fifteen patients were studied. The mean duration + SD of using budesonide was 9.66±15.76 weeks. The mean percentage + SD was 41.33±34.61 for improvement in the volume of food intake, and the mean for improving dysphasia + SD was 42±33.63%. Three patients suffered from complications (i.e., mucositis and gastric fullness). Also, two patients did not want to continue treatment because they did not like the drug taste.Conclusion: Oral budesonide liquid could be recommended for epidermolysis bollusa patients to improve clinical symptoms.
Reza Zare; Narges Ghazi; Farnaz Mohajertehran; Narges Asfiaee; Pendar Argani; Negar Khodaeni; Salehe Akhondian
Abstract
Introduction:Oral lichen planus treatment offers favorable clinical results over time due to its widespread prevalence. However, to date, there is still no theoretical agreement on the cause of this disease. Therefore, the present study aimed to investigate the frequency of human papillomavirus (HPV) ...
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Introduction:Oral lichen planus treatment offers favorable clinical results over time due to its widespread prevalence. However, to date, there is still no theoretical agreement on the cause of this disease. Therefore, the present study aimed to investigate the frequency of human papillomavirus (HPV) DNA in oral lichen planus (OLP) tissue samples by the polymerase chain reaction (PCR) method.Methods:This retrospective study was carried out from 1387 to 1398 on 40 OLP samples (24non-erosive-atrophic and 16 erosive-atrophic forms) in the Oral Pathology Department of Mashhad Dental School. Polymerase chain reaction (PCR) was undertaken to identify HPV-DNA. Subsequently, the samples for HPV-DNA underwent PCR analysis again with the specific primers. The data were analyzed statistically by chi-square and independent t-test test regarding the significance levelof lower than 0.05.Results: The population consisted of 29 women (72.5%) and 11 men (27.5%) with an average age of 49.48± 2.78 years. Human papillomavirus DNA in none of the studied samples (in none of the groups) was detected by PCR. Gender distribution in the studied groups was not significantly different from each other, as the groups did not differ significantly in average age.Conclusion: No HPV-positive samples were observed in oral lichen planus samples based on the recent findings in the current study of the Iranian population. Nevertheless, the patients› demographic data were not meaningfully associated. More sample sizes with a control group and a complete medical history should be recruited in further studies. Using complementary methods to approve the PCR method can help further studies to demonstrate accurate results.