Inducing vascular anastomosis for vascular tissue transplantation and vascular regeneration: In vitro Models and Factors

Document Type : Review


1 Vascular and endovascular surgery research center,Mashhad university of medical science

2 Vascular and endovascular surgery research center, Mashhad medical university,Mashhad,Iran


Anastomosis is a term which means a connection between two tubes or branched passages .Veins and arteries connect to transport blood in the body and this connection is natural anastomosis Whenever a blood vessel becomes blocked anastomosis is a backup pathway for blood flow .As the number of patients with chronic organ failure is increasing there is also a rapid increase in the demand for organ transplantation. As a result of a complicated mechanisms in different studies , activation of some factors including FLT1 (Fms Related Receptor Tyrosine Kinase 1),macrophages ,fibroblast ,hypoxia ,platelet drive growth factor ,fibrin-based tissue ,mature vessel networks ,VEGF( Vascular endothelial growth factor) and mechanical processes are been inducing factors for vascular anastomosis. Certainly, vascular anastomosis models is necessary for in vitro vascular anastomosis formation to cover vessels with perivascular cells in a microfluidic device or discover new surgery techniques. In this study, an attempt was made to collect effective factors in inducing vascular anastomosis.