Document Type : Original article
Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Tuberculosis (TB) is remains as one of the most public health concern that approximately 9.9 million individuals were fell ill with TB and 1.5 million people died from this disease (1-2). Routinely, local tuberculosis control programs follow the DOTS (directly-observed treatment, short-course) strategy that introduced by WHO since 2006 (3)In summary, tuberculosis is one of the top health challenge throughout the worldwide that HIV and emergence of drug-resistant TB confounds this problem. Implementation and evaluation of stewardship can helpful strategy to elimination of tuberculosis and curb drug-resistant TB. Development of new antimicrobial stewardship that guarantee treatment adherence and rapid case detection could be associated with decrease TB burden. According to previous literature, antimicrobial stewardship plans containing ongoing healthcare workers’ education, laboratories modification, formulary restriction as well as optimizing the drug dosage and treatment course could increase case detection and appropriate prescription that reduce drug-resistant TB burden in various geographical region.