Document Type : Original article


1 Department of Internal medicine, School of medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Antimicrobial Resistance Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Department of internal medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran



Background: Based on serological studies the prevalence of Helicobacter pylori infection in Iranian adults is up to 80%. Gastritis, peptic ulcer, and gastric adenocarcinoma are common clinical outcomes of this infection in Iran. Since antibiotic resistance patterns of Helicobacter pylori are different geographically, local studies are highly required.

Method: Eighty isolates of Helicobacter pylori were obtained from patients referred to the endoscopy unit of Ghaem university hospital in Mashhad. Demographic features including age, gender, symptoms were recorded before the sampling. The antibiotic susceptibility patterns of isolates were determined for five common antibiotics used for the treatment of Helicobacter pylori infection. The agar dilution method was used to evaluate the antibiotic resistance patterns.

Results: The patterns of antibiotic resistance were determined and 41.2%, 13.7%, 8.7%, 6.6%, and 6.6% of isolates were resistant to metronidazole, clarithromycin, amoxicillin, tetracycline, and furazolidone, respectively.

Conclusion: Our results demonstrate that the total rate of antibiotic resistance rates of H. pylori especially in the case of metronidazole increased over time. The increase in the rates of resistance was affected by factors such as female sex and ages between 30 to 60 that remind of the need for the continuous monitoring program of antibiotic susceptibility patterns.