Document Type : Original article

Authors

1 Metabolic Research Center, School of Medicine, Mashhad University of Medical Sciences, Iran

2 .Department of Medical Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

3 Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

4 International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran

5 International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.

6 Iranian UNESCO center of excellence for human nutrition, Mashhad University of Medical

7 Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran

8 1: MD, Cardiologist, Department of cardiology, School of Medicine, Mashhad University of medical Sciences, Mashhad, Iran. 2: Cardiovascular Research Center, School of Medicine, Mashhad University of medical Sciences, Mashhad, Iran.

9 MD, Cardiologist, Department of cardiology, School of Medicine, Mashhad University of medical Sciences, Mashhad, Iran Cardiovascular research center

10 Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran

11 Social Determinants of Health Research Center, Mashhad University of Medical sciences, Mashhad, Iran

12 Department of Medical Education, Brighton and Sussex Medical School, Falmer, Brighton, UK.

13 Associate Professor of Health Education and Promotion, Health Sciences Research center ,Department of Health and management, school of health, Mashhad University of Medical Sciences, Mashhad,

14 Biochemistry and Nutrition Research Center and Department of clinical biochemistry, Mashhad University of Medical Sciences, Mashhad, Iran

10.22038/rcm.2022.60548.1378

Abstract

Introduction: Diabetes (DM) is a type of metabolic disorder that its types are generated by collecting of genetic and environmental risk agents. Here, the association between HSPB1 polymorphism as a genetic risk factor and DM was investigated.

methods:

Total 690 participants from MASHAD cohort study population were recruited into the study.

Anti-HSP27-level was assessed followed by genotyping using Taqman®-probes-based assay. Anthropometric, demographic and hematological/biochemical characteristics were evaluated. Kaplan-Meier curves were utilized, while logistic regression models were used to assess the association of the genetic variant with clinical characteristics of population.

Results: Finds was shown there are meaningful differences among groups of age, height, waist circumference, systolic blood pressure, FBG,TG, HDL-C, and hs-CRP, and was no big -significant difference between the exists in different HSP27 SNP in the two studied groups (with and without DM), also was no remarkable relation between genetic forms of HSPB1 and T2DM. This investigation was the first research that analyzed the relationship between the genetic type of the HSPB1 gene (rs2868371) and Type 2 diabetes (DM2). In our population, the CC genotype (68.1%) had a higher prevalence versus GC (26.6%) and GG (5.3%) genotypes and the data shown that no genetic difference of HSPB1 gene polymorphism (rs2868371) was related with DM2.

Conclusion: HSPB1 polymorphism, rs2868371, was not associated with type 2 diabetes mellitus.

Keywords