Five years of a single burn center experience with toxic epidermal necrolysis: retrospective study of causative drugs and the clinical outcome

Document Type : Original article

Authors

1 Lung disease research center, Faculty of Medicine, Mashhad university of Medical Sciences, Mashhad, Iran

2 Surgical Oncology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Assistant professor of Intensive Care medicine, Department of anesthesiology, Faculty of Medicine, Mashhad university of Medical Sciences, Mashhad, Iran.

4 Sub specially in Critical Care Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

5 Post Doctorate of psychosomatic medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, but potentially life-threatening reactions to medications. Both conditions have significant morbidity and mortality. This study aimed to document the epidemiological features, aetiologies, treatment and clinical outcomes of such patients.
Method: In this retrospective cross-sectional study the records of all patients with TEN treated for5 years in central Hospital, Mashhad, Iran were reviewed.
Results: Thirty-four patients were studied with a mean age of 26.5 years. Mean age in the mortality and survivors groups was 33.6 and 25.3 years, respectively. Drugs accounted for all 34 cases were including Anti-convulsants (52.9%) other the most common implicated drug followed by antibiotics (26.5%), allopurinol (5.9%) and multiple drugs (anticonvulsants plus antibiotics) (14.7%). Antibiotics had the shortest interval between ingestion time and onset of symptoms. The mean ICU length of stay was 12.7 days, with a range of 1 to 30 days. The mean of SCORTEN was 2.3; it was 3.3 and 2.1 in the mortality and survivors group, respectively (P=0.001).
All 34 TEN cases were given intravenous immunoglobulins (IVIG). Six patients with TEN died (17.6%). The highest mortality was found in the allopurinol group with 50%, whereas anticonvulsants and antibiotics had a mortality rate of 16.6% and 15.3%, respectively.
Conclusion: Anti-convulsants especially Lamotrigine were the most frequently implicated drug, followed by antibiotics and allopurinol. IVIG was shown beneficial effects in TEN syndrome.

Keywords

Reviews in Clinical Medicine
Volume 9, Issue 2
June 2022
Pages 59-64

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