Document Type : Case report


Sinus and Surgical Endoscopic Research Center, Department of Otorhinolaryngology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


Coronavirus disease 2019 (COVID-19) is one of the most significant medical problems of the century. Mucormycosis infection is one of the devasting problems associated with this disease. Brain abscess associated with these conditions may have very poor prognosis, and prompt diagnosis as well as treatment of it is of paramount importance. In this study, we introduce a diabetic middle-aged man  who was treated with corticosteroids due to COVID-19, and affected by rhinocerebral mucormycosis. Due to eye chemosis, brain MRI was performed  which showed a silent abscess in temporal lobe with no neurological symptoms. After ten weeks of treatment, serial endoscopic sinus surgery and antifungal therapy, the invasive fungal sinusitis and brain abscess healed without debilitating sequala. We introduced this case as an educational example of brain involvement in mucormycosis. Although very rare,  due to possible fatal sequalae, brain abscess should be considered as a probable complication of mucormycosis even if the patient has no neurological symptom.