Metabolic syndrome is negatively associated with trabecular bone score and bone mineral density in normal weight adults with central obesity

Darroudi, Susan; Sharifan, Payam; Rastegar Moghaddam Poorbagher, Mahsa; Mohamadi Bajgiran, Maryam; Saffar Soflaei, Sara; Ghazizadeh, Hamideh; Esmaily, Habibollah; Shabani, Niloofar; Sadeghi, Ramin; Dabbagh Kakhki, Vahid Reza; Ebrahimi Dabbagh, Ali; Mohammadi, Mohammad Amin; Mohammadi, Mohammad Amin; Moazedi, Sara; Rafiee, Mahdi; Assaran Darban, Reza; Ferns, Gordon A.; Mohebati, Mohsen; Ghayour, Majid

doi:10.22038/rcm.2023.72610.1455

Metabolic syndrome is negatively associated with trabecular bone score and bone mineral density in normal weight adults with central obesity

Document Type : Original article

Authors

Susan Darroudi ¹

Payam Sharifan ²

Mahsa Rastegar Moghaddam Poorbagher ³

Maryam Mohamadi Bajgiran ¹

Sara Saffar Soflaei ⁴

Hamideh Ghazizadeh ¹

habibollah esmaily ⁵

Niloofar Shabani ⁶

Ramin Sadeghi ⁷

Vahid Reza Dabbagh Kakhki ⁷

Ali Ebrahimi Dabbagh ⁸

Mohammad Amin Mohammadi ⁸

sara Moazedi ⁸

Mahdi Rafiee ⁹

reza Assaran Darban ¹⁰

Gordon A. Ferns ¹¹

Mohsen Mohebati ¹²

majid Ghayour ¹

¹ International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran

² Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

³ Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran

⁴ International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.

⁵ Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

⁶ Department of Biostatistics, School of Health, Tehran University of Medical Sciences, Tehran, Iran

⁷ Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

⁸ Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran

⁹ Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

¹⁰ Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran 5. Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

¹¹ Department of Medical Education, Brighton and Sussex Medical School, Falmer, Brighton, UK.

¹² Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

10.22038/rcm.2023.72610.1455

Abstract

Introduction: Metabolic syndrome (MetS) is comprised of a clustering of various cardiovascular risk factors that can also affect bone health. We aimed the associations between MetS and bone mineral density (BMD) and trabecular bone score (TBS) in subjects with abdominal adiposity.
Methods: Individuals with body mass index less than 25 kg/m2 were enrolled from the SUVINA study and allocated into two groups according criteria of IDF for metabolic syndrome. TBS T-score and Z/T score of fore skeletal region were measured using dual-energy X-ray absorptiometry (DXA). SPSS software was used for statistical analysis and p value 0<0.05 was considered significant.
Results: DXA measurements were made in 201 participants, of whom 75 had MetS and 126 did not. Scores related to the neck of femur and total femur, radius Z-score and TBST-score were lower in subjects with MetS (all P<0.05). Subjects with FBG≥100 had lower TBST-score (p < 0.05). SBP≥130 and DBP≥85 in subjects, led to the lower TBST-score, and lumbar T-score (both P < 0.05). Subjects with (LDL-C≥160 mg/dl) had lower TBST-score, neck of femur Z score, and total femur T/Z scores (all P < 0.05). TBST-score and scores related to neck of femur, and total femur were lower in participants with serum cholesterol≥200 mg/dl (P < 0.05).
Conclusion: MetS is negatively associated with TBS and BMD scores. Higher levels of LDL-C and cholesterol were the most associated factors related to TBST-score decrease. The neck of femur was the most vulnerable skeletal against the MetS components increment.

Keywords

Trabecular bone score

Bone mineral density

Metabolic syndrome

Serum lipids