Document Type : Original article
Authors
1 Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Department of Neurology, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran.
3 Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract
Introduction: In multiple sclerosis (MS), oxidative stress (OS) performs a vital role in the neurodegeneration process. Cholesterol and lipids in the myelin sheath supplied by low-density lipoprotein (LDL) are also vital for nerve cells. In OS, lipid peroxidation occurs in LDL.
Objective: To investigate the OS biomarker such as prooxidant-antioxidant balance (PAB), malondialdehyde (MDA) and their correlation with LDL and oxidized LDL (Oxi-LDL) in patients with relapsing-remitting MS.
Methods: Blood samples from 18 patients with relapsing-remitting MS and 18 healthy subjects were collected to measure the OS biomarkers.
Results: In the patients' group in comparison to the control group: PAB, white blood cells (WBC), and neutrophils significantly increased (P<0.05), but there was no difference between the relapsing and remitting phase; MDA significantly increased in the relapsing phase (P=0.013), but marginally significant in remitting (P=0.068). There was no significant difference in LDL and Oxi-LDL between the two groups. Only the lymphocytes were different between the relapse and remission phases.
Conclusion: The importance of OS in the process of MS disease was confirmed and a PAB assay can be used for the determination of OS levels.
Keywords
)