Introduction
Nasal airway is the preferred airway during sleep in normal conditions; on the other hand, most of our airway resistance is determined by nasal airway (1). Therefore, obstructing pathologies will increase the resistance to airflow and this will lead to higher negative intraluminal pressure and higher possibility of pharyngeal collapse (2). Considering these facts, one can predict the coexistence of nasal obstructing pathologies and sleep related breathing disturbances. Sleep apnea is the most common of these disturbances and it is characterized by temporary obstructions of upper airway during sleep. These disturbances will lead to daytime sleepiness or fatigue which may cause daytime dysfunction and alter quality of life. Therefore, addressing obstructing pathologies that cause sleep disturbances is necessary.
This review article will discuss the results of relieving the nasal obstruction by surgery on sleep apnea.

The relation between nasal obstruction and breathing disturbances during sleep
There are many studies about the relation between nasal obstruction and sleep disorder breathing (SDB). There are two types of studies in this regard. The first group studied the relationship between SDB and obstructing pathologies (anatomic or inflammatory), in the second group, the obstruction was simulated artificially and the relationship to SDB was studied.
Wisconsin cohort study, on 1032 patients, showed the nighttime nasal congestion was an independent risk factor for habitual snoring. In patients with severe nasal congestion (every night or almost every night), there was a 3-fold increase in the possibility of habitual snoring that was independent from sex, age, body mass index, cigarette smoking and asthma (3).  
Iofaso et al. performed an anterograde study on 528 patients with snoring and reported nasal obstruction as an independent OSA (obstructive sleep apnea) risk factor. In this study, nasal obstruction was confirmed with posterior rhinomanometry and AHI (apnea-hypopnea index)>15 was considered as OSA existence. Nasal obstruction was the reason for 2/3 % of total AHI variance (4). In 2002, Serrano carried out a study on 10033 patients with nasal polyposis and showed the negative results of nasal polyposis on quality of life and sleep. In this study, they used questionnaires to evaluate the effects of nasal disease on the quality of life and sleep disorder. 50.5 percent of patient with polyposis had snoring, while this was 35.7 in normal population (5).
In studies, in which nasal obstruction was simulated artificially, there was a correlation between nasal obstruction and SDB. Nasal packing, for example, was associated with more apnea and microarousals, reduction in deep sleep status, worse oxygen desaturation index and in general, lower quality of sleep (6-8).

Effective mechanisms proposed for coexistence of nasal obstructions and SDB
As already mentioned, one of the factors involved in SDB, is anatomic or inflammatory pathologies obstructing the nasal airway. In this section, we paid attention to the mechanisms describing the relationship between nasal obstruction and SDB.

1. Increased airway resistance (starling model)
Regarding this model, the entrance with a relative resistance is in the nose and the collapsible segment is in the oropharynx. Therefore, one can predict that increased nasal airway resistance will cause increased negative oropharyngeal airway pressure and collapse (9).            

2. Change from nasal breathing to oral breathing
The preferred airway in a normal person is the nasal airway. This is true in the sleep or awake time (10). If the nasal airway is blocked, breathing is switched to oral airway but this causes some physiologic problems. During oral breathing, total airway resistance increases 2.5 fold (11). On the other hand, during oral breathing, mandible moves downward and backward and tongue will do the same. This retraction will cause retroglossal diameter to decrease (12). A study showed that mouth opening with 1.5 centimetre (cm) distance between incisors, will cause 1 cm mandibular angle dislocation (13). These factors will increase upper airway collapse.

3. Disturbed nasal reflexes
Nasal receptor, which is activated during nasal breathing, will have positive effect on autonomous ventilation. In fact, studies showed that not only minute ventilation is larger with nasal breathing but also increasing nasal flow will result in increased minute ventilation (14). After nasal obstruction, nasal airway is bypassed and nasal receptor functions will decline. Thus, muscle tone, respiratory rate and minute ventilation decrease. There are studies showing that blocking the function of these receptors by local anesthesia will result in more obstructive apnea and lower genioglossus muscle activity (15,16).

The effect of nasal surgery on sleep breathing disorder
Accepting the hypothesis that nasal obstruction will cause SDB, based on previously mentioned studies, is logical to observe recovery if nasal obstruction is relieved.
In this review, we discussed the effect of nose surgical treatment on the breathing pattern in the patients with nasal obstruction during sleep. (Table 1)
In contrast to studies trying to evaluate the effect of medical therapies and nasal dilators on breathing disorder during sleep for nasal pathologies, randomized controlled trials evaluating the effect of surgery for nasal obstruction on sleep apnea are few. Most current idea in this field is based on case series.
On the other hand, in these studies, pathologies creating nasal obstruction were heterogenous such as septal deviation, nasal vault deformity, inferior conchal hypertrophy and nasal polyposis. Even in one study, the researchers used different surgical options for a myriad of different obstructive pathologies. Surgical success was also defined differently. Thus, it is difficult to compare the effect of nasal airway surgery on SDB in different studies.
The effect of nasal surgery on sleep parameters are divided into two categories, subjective and objective. Objective parameters are from polysomnographic data but subjective parameters were different in various studies and are based on quality of life questionnaire, bed partner data and Epworth sleepiness scale.In our review literature study, we evaluated the effect of nasal surgery on apnea-hypopnea index, the most important polysomnographic parameter.
Most studies evaluating the effect of nasal surgery on OSA during the past 3 decades showed that nasal surgery is not successful in the improvement of objective sleep parameters. Studies in 1980s and 1990s evaluating the effects of septoplasty on snoring used subjective criteria (questionnaire or visual analog scale) and showed decreased snoring with a rate of 50-75% (17-19).Verse et al. did a meta-analysis in 2003 (20) and they mentioned that only 9 study had data about AHI before and after nasal surgery until 2000. Overall, these studies had 102 patients with OSA and had a short follow-up period of 1 month to 44 months. Of these studies, one study (21) reported a statistically significant improvement in OSA severity (AI decreased from 37.8 to 26.7). The final result of this meta-analysis was that the overall success rate of nasal surgeries about OSA was lower than 20 percent (20).
Studies during 1999 to 2009 about nasal surgery and sleep apnea were the basis of another meta-analysis by Li et al. in 2011. This meta-analysis contained 13 studies and the weighted mean AHI in nine studies decreased from 35.2±22.6 to 33.5±23.8 postnasal surgery (P=0.69). According to this study, the overall success rate of nasal surgery was 16.7 percent in OSA treatment (22).
Evaluating the studies in Li ҆s meta-analysis separately, showed that there was no statistically significant decrease in AHI except for one study (23). This study was conducted by Kim et al. on 21 patients with nasal obstruction and snoring and they evaluated the effect of septoplasty and conchal resection on sleep apnea. The results of this study were the following: respiratory disturbance index (RDI) decreased from 39 to 29 (P=0.0001) and apnea index decreased from 19 to 16 (P=0.0209). In fact, this was the only study in Li meta-analysis that showed improvement in polysomnographic parameters post-surgery (23).
Other studies evaluated the effect of nasal surgery on sleep apnea in recent years. Choi (24) and Sufioglu (25), in two separate studies, evaluated the effect of nasal surgery on OSA and finally concluded that despite improvement in sleep structure, there was no statistically significant change in AHI, arousal or minimum arterial O2 saturation. In Sufioglu et al. study, the mean apnea-hypopnea duration showed a decrease (25).
The only randomized single-blind controlled trial by Koutsourelakis et al. on 49 patients with OSA and nasal obstruction due to septal deviation, compared septoplasty and sham surgery and showed no statistically significant difference in AHI and minimal O2 saturation (26).
On the other hand, there are several studies that have not shown sleep parameters improvement postnasal surgery, but have indicated worsening of breathing status during sleep. Verse et al. studied two patients with nasal polyposis. AHI and excessive daily sleepiness increased unexpectedly post-FESS (functional endoscopic sinus surgery) and REM duration decreased (27).
Freidman et al. studied the effect of septoplasty and inferior conchal resection on 50 patients with nasal obstruction and OSA. They concluded that RDI level in patients with mild obstructive apnea significantly increased. In this study, total RDI level also showed an increase (31.6 before surgery and 39.5 after surgery), but this increase was not significant (28). The justification of these researchers was that the improvement of nasal breathing after surgery as well as accommodation of patients to polysomnography test conditions resulted in deeper sleep which increased the possibility of airway collapse. Paradoxical results from these studies indicate that one cannot judge the effect of nasal surgery on sleep quality and this needs further evaluation.

Causes of nasal surgery failure on polysomnographic parameter improvement

1. Not paying attention to multilevel assessment in upper airway evaluation Series et al. study showed that normal cephalometry would help to determine the group of patients with nasal obstruction and mild OSA who will benefit from operation. According to this study, all patients except for one had improvement in AHI and