Document Type : Original article
Authors
- Ahmad shah Farhat 1
- Ashraf Mohammadzadeh 2
- Ezzat Khodashenas 3
- saeed reza lotfi 4
- negar yeganeh khorasani 5
1 Assistant Professor of Neonatal Research, Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2 Professor of Pediatrics Department of Pediatrics, School of Medicine Neonatal Research Center Imam Reza Hospital Mashhad University of Medical Sciences
3 Associated Professor of Neonatal Research, Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4 Neonatologist, samen hospital , Mashhad, Iran
5 Student Research Committee, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Introduction: Neonatal jaundice is a very important problem that occurs in 80% of premature infants. Treatments for jaundice include phototherapy and blood transfusions. But phototherapy is expensive and covering the eyes disrupts the relationship between mother and child. Also, in bilirubin above 20, the power of reducing bilirubin due to phototherapy is not so high
Methods: Samples will be selected by the probabilistic method. The infants were admitted to the study at the NICU of Imam Reza and Samen Al-A'meh Hospitals in Mashhad. Random allocation is given in one of the two phenobarbital or case and the placebo groups. Routine laboratory tests for jaundice are performed for all infants. Then phototherapy and medicine are prescribed. Bilirubin levels are checked every 6, 12, 24, and 48 hours after medication and until discharge. After collecting information, the data is analyzed with SPSS software version 16.
Results: According to these results, there were no significant differences between sex, gestational age, infant weight and age in two groups. The mean and standard deviation of bilirubin levels before the intervention and after intervention were not significantly different between the two groups after 6 , 12, 24,48 hours, and discharge time.
Conclusion: Phototherapy with 20 mg/kg phenobarbital was prescribed for the study group and only phototherapy was performed for the control group. In neonates with jaundice, phototherapy with phenobarbital 20 mg single dose did not reduce bilirubin levels and length of hospital stay.
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