Ahmad shah Farhat; Ashraf Mohammadzadeh; Ezzat Khodashenas; saeed reza lotfi; negar yeganeh khorasani
Abstract
Introduction: Neonatal jaundice is a very important problem that occurs in 80% of premature infants. Treatments for jaundice include phototherapy and blood transfusions. But phototherapy is expensive and covering the eyes disrupts the relationship between mother and child. Also, in bilirubin above 20, ...
Read More
Introduction: Neonatal jaundice is a very important problem that occurs in 80% of premature infants. Treatments for jaundice include phototherapy and blood transfusions. But phototherapy is expensive and covering the eyes disrupts the relationship between mother and child. Also, in bilirubin above 20, the power of reducing bilirubin due to phototherapy is not so highMethods: Samples will be selected by the probabilistic method. The infants were admitted to the study at the NICU of Imam Reza and Samen Al-A'meh Hospitals in Mashhad. Random allocation is given in one of the two phenobarbital or case and the placebo groups. Routine laboratory tests for jaundice are performed for all infants. Then phototherapy and medicine are prescribed. Bilirubin levels are checked every 6, 12, 24, and 48 hours after medication and until discharge. After collecting information, the data is analyzed with SPSS software version 16.Results: According to these results, there were no significant differences between sex, gestational age, infant weight and age in two groups. The mean and standard deviation of bilirubin levels before the intervention and after intervention were not significantly different between the two groups after 6 , 12, 24,48 hours, and discharge time. Conclusion: Phototherapy with 20 mg/kg phenobarbital was prescribed for the study group and only phototherapy was performed for the control group. In neonates with jaundice, phototherapy with phenobarbital 20 mg single dose did not reduce bilirubin levels and length of hospital stay.
Ashraf Mohammadzadeh; Ahmad shah Farhat; Ezzat Khodashenas; Jalil Tavakol Afshari; Nafiseh Pourbadakhshan; Mehdi Sohrabi
Abstract
Background: The study aimed to determine the effect of zinc consumption on cell immunity in healthy 6-year-old children. In a double-blind clinical trial after the license of parents, 40 children 6-7 years old were enrolled. The male healthy and 6-7-year-old children were included and those with chronic ...
Read More
Background: The study aimed to determine the effect of zinc consumption on cell immunity in healthy 6-year-old children. In a double-blind clinical trial after the license of parents, 40 children 6-7 years old were enrolled. The male healthy and 6-7-year-old children were included and those with chronic disease, failure to thrive, and usage of another zinc supplement in the past two months, were excluded. In the case group (N=20), twenty mg of zinc sulfate syrup has been prescribed orally for 6 months. The control group (N=20) received a placebo the same as the case group in the volume, color, bottle size, and shape. Serum zinc level and cellular proliferation were measured before intervention and 12 hours after the last dose of zinc sulfate. Zinc serum was measured by manual colorimetric method technique. A zinc level of less than 65 ug/dl is considered zinc deficiency. The lymphocyte proliferation before and after zinc treatments have been compared by paired T-test analysis. Results:The mean weight of children in the case and control group were 20.37±2.21kg and 20.92±1.98 kg respectively (P= >0.05). Serum zinc level was within the normal limit and did not differ between the two groups before and after intervention (P=0.86). After 6 months of supplementation of 20 mg zinc sulfate per day for 6 months, there were no significant improvements in Lymphocyte proliferation (with/without PHA). Conclusion: This study indicates that moderate supplementation of zinc for six months cannot efficiently improve Lymphocyte proliferation (with/without PHA) in healthy male children.
Ashraf Mohammadzadeh; Ezzat Khodashenas; Ahmad Shah Farhat; Nafiseh Pourbadakhshan; Ali Jafarzadeh Esfehani; Mehdi Sohrabi; Aradokht Vaezi
Abstract
Introduction: Zinc has a key role in reproductive physiology, immune modulation, growth, and development. To determine the effect of zinc supplements on the anthropometry of healthy 6-yearold children.Methods: In this double-blind placebo-controlled trial was carried out on 40 children 6-7 years old. ...
Read More
Introduction: Zinc has a key role in reproductive physiology, immune modulation, growth, and development. To determine the effect of zinc supplements on the anthropometry of healthy 6-yearold children.Methods: In this double-blind placebo-controlled trial was carried out on 40 children 6-7 years old. The intervention group (n=20) received 20mg of oral zinc sulfate syrup and the control group (n=20) received a placebo daily in the same buttle and same test for 6 months duration of study. Serum zinc levels and anthropometric measurements (weight, height, head circumference, and arm circumference) were measured before and after intervention. Zinc deficiency was defined as serum zinc level < 9.9 μmol/l.Results: Serum zinc level did not differ between the two groups (P=0.86). Zinc supplementation resulted in a significant increase in height (P= 0.008).Conclusion: This study showed that zinc supplements have a significant increase in the length of male 6-year-old children.
Ashraf Mohammadzadeh; Nafiseh Pourbadakhshan; Ahmad Shah Farhat; Azin Vaezi
Abstract
Introduction: Gestational diabetes is a multifactorial disease that genetic and environmental factors affect insulin sensitivity. This study was designed with consideration towards the importance of micronutrients in carbohydrate metabolism.Methods: The present case-control study was performed on 100 ...
Read More
Introduction: Gestational diabetes is a multifactorial disease that genetic and environmental factors affect insulin sensitivity. This study was designed with consideration towards the importance of micronutrients in carbohydrate metabolism.Methods: The present case-control study was performed on 100 pregnant women referred to Imam Reza Hospital in Mashhad, Iran. Fifty pregnant women with gestational diabetes as defined by the American Diabetes Association guideline were considered as the case group and 50 non-diabetic pregnant women formed the control group. Maternal demographic information was recorded in the checklist . Serum levels of zinc, copper, selenium and chromium were measured in both groups. After data collection, they were processed with spss16 software.Results:The mean age of diabetic and non-diabetic pregnant mothers was 32.33 ± 5.92 and 26.32 ± 5.38 years respectively, and their mean weight was 82.87 ± 10.81 kg in the case and 73.18 ± 10.6 kg in the control group. Maternal weight and age in the gestational diabetes group were significantly higher. (both p < 0.05). There was a significant difference between the case and control groups in terms of family history of diabetes in first-degree relatives; history of formula fed mothers during infancy, gravid > 3 ,and low gestational age were all more common in women with gestational diabetes (p < 0.05). In contrast to chromium, serum levels of zinc, copper and selenium were higher in the group with gestational diabetes.Conclusion: No significant relation was observed between serum zinc, copper, chromium and selenium levels with gestational diabetes.