Ahmad shah Farhat; Ashraf Mohammadzadeh; Ezzat Khodashenas; saeed reza lotfi; negar yeganeh khorasani
Abstract
Introduction: Neonatal jaundice is a very important problem that occurs in 80% of premature infants. Treatments for jaundice include phototherapy and blood transfusions. But phototherapy is expensive and covering the eyes disrupts the relationship between mother and child. Also, in bilirubin above 20, ...
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Introduction: Neonatal jaundice is a very important problem that occurs in 80% of premature infants. Treatments for jaundice include phototherapy and blood transfusions. But phototherapy is expensive and covering the eyes disrupts the relationship between mother and child. Also, in bilirubin above 20, the power of reducing bilirubin due to phototherapy is not so highMethods: Samples will be selected by the probabilistic method. The infants were admitted to the study at the NICU of Imam Reza and Samen Al-A'meh Hospitals in Mashhad. Random allocation is given in one of the two phenobarbital or case and the placebo groups. Routine laboratory tests for jaundice are performed for all infants. Then phototherapy and medicine are prescribed. Bilirubin levels are checked every 6, 12, 24, and 48 hours after medication and until discharge. After collecting information, the data is analyzed with SPSS software version 16.Results: According to these results, there were no significant differences between sex, gestational age, infant weight and age in two groups. The mean and standard deviation of bilirubin levels before the intervention and after intervention were not significantly different between the two groups after 6 , 12, 24,48 hours, and discharge time. Conclusion: Phototherapy with 20 mg/kg phenobarbital was prescribed for the study group and only phototherapy was performed for the control group. In neonates with jaundice, phototherapy with phenobarbital 20 mg single dose did not reduce bilirubin levels and length of hospital stay.
Ashraf Mohammadzadeh; Ahmad shah Farhat; Ezzat Khodashenas; Jalil Tavakol Afshari; Nafiseh Pourbadakhshan; Mehdi Sohrabi
Abstract
Background: The study aimed to determine the effect of zinc consumption on cell immunity in healthy 6-year-old children. In a double-blind clinical trial after the license of parents, 40 children 6-7 years old were enrolled. The male healthy and 6-7-year-old children were included and those with chronic ...
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Background: The study aimed to determine the effect of zinc consumption on cell immunity in healthy 6-year-old children. In a double-blind clinical trial after the license of parents, 40 children 6-7 years old were enrolled. The male healthy and 6-7-year-old children were included and those with chronic disease, failure to thrive, and usage of another zinc supplement in the past two months, were excluded. In the case group (N=20), twenty mg of zinc sulfate syrup has been prescribed orally for 6 months. The control group (N=20) received a placebo the same as the case group in the volume, color, bottle size, and shape. Serum zinc level and cellular proliferation were measured before intervention and 12 hours after the last dose of zinc sulfate. Zinc serum was measured by manual colorimetric method technique. A zinc level of less than 65 ug/dl is considered zinc deficiency. The lymphocyte proliferation before and after zinc treatments have been compared by paired T-test analysis. Results:The mean weight of children in the case and control group were 20.37±2.21kg and 20.92±1.98 kg respectively (P= >0.05). Serum zinc level was within the normal limit and did not differ between the two groups before and after intervention (P=0.86). After 6 months of supplementation of 20 mg zinc sulfate per day for 6 months, there were no significant improvements in Lymphocyte proliferation (with/without PHA). Conclusion: This study indicates that moderate supplementation of zinc for six months cannot efficiently improve Lymphocyte proliferation (with/without PHA) in healthy male children.
Ashraf Mohammadzadeh; Ezzat Khodashenas; Ahmad Shah Farhat; Nafiseh Pourbadakhshan; Ali Jafarzadeh Esfehani; Mehdi Sohrabi; Aradokht Vaezi
Abstract
Introduction: Zinc has a key role in reproductive physiology, immune modulation, growth, and development. To determine the effect of zinc supplements on the anthropometry of healthy 6-yearold children.Methods: In this double-blind placebo-controlled trial was carried out on 40 children 6-7 years old. ...
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Introduction: Zinc has a key role in reproductive physiology, immune modulation, growth, and development. To determine the effect of zinc supplements on the anthropometry of healthy 6-yearold children.Methods: In this double-blind placebo-controlled trial was carried out on 40 children 6-7 years old. The intervention group (n=20) received 20mg of oral zinc sulfate syrup and the control group (n=20) received a placebo daily in the same buttle and same test for 6 months duration of study. Serum zinc levels and anthropometric measurements (weight, height, head circumference, and arm circumference) were measured before and after intervention. Zinc deficiency was defined as serum zinc level < 9.9 μmol/l.Results: Serum zinc level did not differ between the two groups (P=0.86). Zinc supplementation resulted in a significant increase in height (P= 0.008).Conclusion: This study showed that zinc supplements have a significant increase in the length of male 6-year-old children.
Elaheh Heidari; Maryam Emadzadeh; Ezzat Khodashenas; Farideh Najm Sarvari; Hamid Ahanchian; Amin Heidari; Mahdi Mottaghi
Abstract
Introduction: Bronchiolitis is the main cause of lower respiratory tract infection during the first year of life. This systematic review aimed to assess the effectiveness of systemic corticosteroids in the treatment of bronchiolitis in children aged less than two years during their first hospitalization.Methods: ...
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Introduction: Bronchiolitis is the main cause of lower respiratory tract infection during the first year of life. This systematic review aimed to assess the effectiveness of systemic corticosteroids in the treatment of bronchiolitis in children aged less than two years during their first hospitalization.Methods: This systematic review was conducted via searching in databases such as PubMed, Scopus, Web of Science, and Cochrane Library until August 2019. Randomized clinical trials regarding the effects of systemic corticosteroids on children with bronchiolitis aged less than two years were evaluated in the retrieved studies. The quality of the studies was assessed based on the Jadad scale. Result: Three studies were included in this systematic review. In two studies, dexamethasone versus placebo were used, and in one study, prednisolone was applied. In one study, use of dexamethasone versus placebo resulted in the faster resolution of respiratory distress, shorter duration of respiratory distress syndrome, reduced oxygen therapy time, and reduced length of hospital stay. In another study, children receiving treatment with dexamethasone had no significant difference in the clinical score, respiratory rate, and pulmonary function compared to the control group. In another study, use of prednisolone within two weeks led to the partial improvement of rhinitis, wheezing, breathing problems, nocturnal respiratory symptoms, and coughing. However, no significant difference was observed between the prednisolone treatment and control groups after 12 months.Conclusion: Despite the improvements in respiratory symptoms, evidence is scarce regarding the effectiveness of systemic corticosteroids in the treatment of bronchiolitis in children aged less than two years. Therefore, well-designed randomized clinical trials on large sample sizes are required in this regard.
Ezzat Khodashenas; Alireza Ataei Nakhaei; Elahe Heidari
Abstract
The purpose of this study is to report a case of severe back pain following lumbar puncture (LP), which was associated with an accidental tether cord syndrome (TCS) in MRI. The patient was a 10-year-old boy that was hospitalized in the pediatric ward for severe headache and to rule out meningitis. First, ...
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The purpose of this study is to report a case of severe back pain following lumbar puncture (LP), which was associated with an accidental tether cord syndrome (TCS) in MRI. The patient was a 10-year-old boy that was hospitalized in the pediatric ward for severe headache and to rule out meningitis. First, LP was performed for him, but he suffered very severe back pain after LP. Lumbosacral MRI was performed to rule out collection or abscess formation, but the evidence of the TCS was accidentally found; however, it was too unexpected before. In the short term follow up, the symptoms of the patient were completely resolved by using analgesics. It was shown that his pain was as a result of LP. In general, although sometimes severe lower back pain after LP may be overwhelming, if neurologic examination were normal, it is important to assure parents that it would be resolved.