Zahed Ahmadi
Abstract
This article discusses regarding the impact of night shift work on osteoporosis using evidences from epidemiological evidences. Nowadays, night shift work is characterized as a common risk factors which contributes in decrease of bone mineral density (BMD) content as well as increase of bone fracture ...
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This article discusses regarding the impact of night shift work on osteoporosis using evidences from epidemiological evidences. Nowadays, night shift work is characterized as a common risk factors which contributes in decrease of bone mineral density (BMD) content as well as increase of bone fracture risk (1). Osteoporosis is defined by the National Institutes of Health (NIH) as "a skeletal disorder characterized by compromised bone strength, predisposing a person to an increased risk of fracture." BMD, a measure of bone strength, is assessed via dual-energy X-ray absorptiometry (DXA), with fractures most common in the hip, spine, and forearm. According to the International Osteoporosis Foundation, approximately 9 million low-energy fractures occur globally each year, affecting more than 200 million women, especially those over the age of 60 (1-2).In conclusion, the findings from current evidences support an association between night shift work and osteoporosis. Based on the available evidence shift work could impacted on mineral bone density through various mechanism such as normal homostasis, dysregulation of endocrin-hormones and immune system to alternating the bone mineral density content. However, the current body of research is limited, and further studies are needed to clarify the link between night shift work and osteoporosis, as well as the underlying biological mechanisms.
Susan Darroudi; Payam Sharifan; Mahsa Rastegar Moghaddam Poorbagher; Maryam Mohamadi Bajgiran; Sara Saffar Soflaei; Hamideh Ghazizadeh; habibollah esmaily; Niloofar Shabani; Ramin Sadeghi; Vahid Reza Dabbagh Kakhki; Ali Ebrahimi Dabbagh; Mohammad Amin Mohammadi; Mohammad Amin Mohammadi; sara Moazedi; Mahdi Rafiee; reza Assaran Darban; Gordon A. Ferns; Mohsen Mohebati; majid Ghayour
Abstract
Introduction: Metabolic syndrome (MetS) is comprised of a clustering of various cardiovascular risk factors that can also affect bone health. We aimed the associations between MetS and bone mineral density (BMD) and trabecular bone score (TBS) in subjects with abdominal adiposity.Methods: Individuals ...
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Introduction: Metabolic syndrome (MetS) is comprised of a clustering of various cardiovascular risk factors that can also affect bone health. We aimed the associations between MetS and bone mineral density (BMD) and trabecular bone score (TBS) in subjects with abdominal adiposity.Methods: Individuals with body mass index less than 25 kg/m2 were enrolled from the SUVINA study and allocated into two groups according criteria of IDF for metabolic syndrome. TBS T-score and Z/T score of fore skeletal region were measured using dual-energy X-ray absorptiometry (DXA). SPSS software was used for statistical analysis and p value 0<0.05 was considered significant.Results: DXA measurements were made in 201 participants, of whom 75 had MetS and 126 did not. Scores related to the neck of femur and total femur, radius Z-score and TBST-score were lower in subjects with MetS (all P<0.05). Subjects with FBG≥100 had lower TBST-score (p < 0.05). SBP≥130 and DBP≥85 in subjects, led to the lower TBST-score, and lumbar T-score (both P < 0.05). Subjects with (LDL-C≥160 mg/dl) had lower TBST-score, neck of femur Z score, and total femur T/Z scores (all P < 0.05). TBST-score and scores related to neck of femur, and total femur were lower in participants with serum cholesterol≥200 mg/dl (P < 0.05).Conclusion: MetS is negatively associated with TBS and BMD scores. Higher levels of LDL-C and cholesterol were the most associated factors related to TBST-score decrease. The neck of femur was the most vulnerable skeletal against the MetS components increment.