Hamid Reza Kianifar
Volume 1, Issue 1 , February 2014, , Pages 1-1
Abstract
The Journal of Reviews in Clinical Medicine (RCM) is the leading journal of its type at Mashhad University of Medical Sciences covering all aspects of the natural and clinical sciences, which may be a matter of concern for the related specialists. The scope of the journal defines the RCM Publishing ...
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The Journal of Reviews in Clinical Medicine (RCM) is the leading journal of its type at Mashhad University of Medical Sciences covering all aspects of the natural and clinical sciences, which may be a matter of concern for the related specialists. The scope of the journal defines the RCM Publishing Group’s ambition to take a considerable step forward in constructing a valuable medical resource for both authors and readers. It offers the practical and the professional support for clinicians to spread the critical and constructive analysis in a specific field through extended explanations on the topic. In other words, it pragmatically provides the readers with recent advances and discoveries by means of previously published literature or data. Furthermore, the journal expects to generate the ideas of where the researches might go in the future. The RCM Publishing Group hopes to be a gateway to the positive outlook of research in any medical discipline. In this issue, we present the wide range of researches in different fields of medicine, which describe briefly below. Acute lymphoblastic leukemia (ALL) is one of the most common pediatric disorders that affected the large number of patients. Along with the high rate of treatment success, a modified and individualized diagnostic test can significantly increase the survival rate. Therefore, cytogenetic and molecular tests might play an important role in the prognosis of ALL by detecting the special genetic polymorphism affecting drug metabolism and its subsequent effective level and toxicity. Differential diagnosis between benign and malignant brain tumors has been a dilemma for appropriate management and treatment for years. Magnetic resonance spectroscopy is now addressing the need for noninvasive methods of measuring human brain function. Chronic kidney diseases such as renal failure are considered as the devastating medical problems in different age group. The longterm appropriate medical care especially nutritional support can exert a positive effect on patients` health. Furthermore, the use of tranexamic acid in cardiac surgery and its complications such as bleeding, the use of herbal medicine in the treatment of refractive seizure in children, the different causes of coma in pediatric medicine and also peripheral nervous system destruction occurred in systemic vasculitis has been discussed. Finally, we focus on cyclooxygenase 2 (COX2) as a major overexpressing enzyme in cancers. Thus, clinicians may consider COX 2 inhibitors as one of the therapeutic agents. The previous studies evaluated this role are reviewed in Wilms` tumor. Above all, we want to express our appreciation to all those who have submitted their manuscripts to RCM journal, all the Editorial board members and all the dedicated staffs for their loyal and precious cooperation. We look forward to attracting more specialists, residents and medical students to make RCM a really international and multicultural journal. Frankly, this has promised to be a far more difficult task than we anticipated. However, we will continue our efforts to take the first steps in this evolution more effectively.
Behnaz Boroumand Rezazadeh; Hamid Zamani Moghadam; Mohammad Gharavifard
Abstract
Ketamine, among wide variety of sedative drugs, has shown beneficial effects when using during the procedural sedation, specifically in pediatrics. Various parameters should be considered in order to perform a safe and effective procedural sedation including optimum dosage of the sedative, administration ...
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Ketamine, among wide variety of sedative drugs, has shown beneficial effects when using during the procedural sedation, specifically in pediatrics. Various parameters should be considered in order to perform a safe and effective procedural sedation including optimum dosage of the sedative, administration methods of sedation, and need for applying any adjuvant drug. In this study, we aimed to review the studies, which have compared the efficacy of the different ways of the injection of ketamine such as intravenous or intramuscular ketamine application. Based on data obtained from the related articles, efficacy and safety of these two methods of ketamine usage in the pediatric procedural sedation were widely similar, but the intravenously administration of the ketamine can be proposed as the preferable mode.
Reza Boostani; Fariborz Rezaeitalab; Behzad Pourmokhtari; Amirali Ghahremani
Abstract
Obstructive sleep apnea syndrome (OSAS) is a common disorder characterized by recurrent apnea during sleep. Nocturnal laboratory-based polysomnography (PSG) is the gold standard test for diagnosis of OSA. The sufferers may complain from daytime sleepiness, snoring or occasional headaches. Serious consequences ...
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Obstructive sleep apnea syndrome (OSAS) is a common disorder characterized by recurrent apnea during sleep. Nocturnal laboratory-based polysomnography (PSG) is the gold standard test for diagnosis of OSA. The sufferers may complain from daytime sleepiness, snoring or occasional headaches. Serious consequences such as cardiovascular complications, stroke or symptoms of depression may complicate the syndrome. Headache prevalence due to sleep apnea is estimated 1%-2% in general population and affects 2%-8% of middle age population. Morning headache is more common in the OSAS patients. OSAS patients present with various characteristics of morning headache. Treatment with continuous positive airway pressure usually reduces headache. The pathophysiologic background for a relation between obstructive sleep apnea and morning headache is multifactorial. Some theories have been proposed for OSAS-related headaches such as changing oxygen saturation during sleep, cerebral vasodilation and increased intracranial pressure due to cerebral vasodilation, sleep disruption and depression but the definite cause of headaches in OSAS patients is not yet clear.
Ali Shamsa
Abstract
Introduction: Magnetic resonance spectroscopy (MRS) is an imaging technique that provides spectroscopic information about changes in biological markers. Studies suggest that MRS can be helpful in determining the prognosis of patients with diffuse axonal injury (DAI).Methods: The PubMed and Scopus databases ...
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Introduction: Magnetic resonance spectroscopy (MRS) is an imaging technique that provides spectroscopic information about changes in biological markers. Studies suggest that MRS can be helpful in determining the prognosis of patients with diffuse axonal injury (DAI).Methods: The PubMed and Scopus databases were systematically searched in June 2015 using following search strategy: (“Magnetic resonance spectroscopy” OR MRS OR “MR spectroscopy”) AND [(“Diffuse axonal injury” OR DAI] AND Prognosis) to find relevant articles in which the prognostic value of MRS had been investigated in patients with traumatic DAI. All relevant information was extracted from the identified articles and used to synthesize the data for the purpose of this study.Result: In total, 19 articles were found in PubMed and 151 in Scopus. Of these, eight documents were selected for further data extraction following the application of the inclusion/exclusion criteria. The total number of patients who participated in the research studies described in the selected documents was 197. All of the selected documents showed that MRS can be used to quantitatively assess metabolite changes in patients with DAI.Discussion: The results of the studies indicate that MRS imaging as a sensitive method can quantitatively determine even small variations in metabolites. Any changes in the metabolite level of the brain after traumatic injury may be a useful predictor of a patient’s outcome; therefore, if the sensitivity of MRS is proven, this method can have prognostic value when employed with patients with DAI.Conclusion: Based on the results of this systematic review, MRS is a sensitive tool that is helpful in determining the prognosis of patients with DAI.
Samaneh Sajjadi; Sepideh Hejazi; Ghazaleh Azami; Mina Akbari; Fatemeh Akbari
Abstract
Pulmonary arterial hypertension (PAH) is characterized by the mean pulmonary artery pressure of more than 25 mmHg and pulmonary artery wedge pressure of less than 15 mmHg evidenced by right-heart catheterization. In the classification of PAH, some subgroups are defined as primary or secondary PAH based ...
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Pulmonary arterial hypertension (PAH) is characterized by the mean pulmonary artery pressure of more than 25 mmHg and pulmonary artery wedge pressure of less than 15 mmHg evidenced by right-heart catheterization. In the classification of PAH, some subgroups are defined as primary or secondary PAH based on the underlying etiologies of the disease. Early episodes of PAH have been reported to occur at younger ages and in women in idiopathic or familial forms with the survival rate of 1-3 years. According to recent registries, the affected patients are older and have better survival rates. Some of the key elements in the pathophysiology of PAH include intima and media proliferation, vascular remodeling, and blood coagulation, which could increase the defiance of pulmonary vascularity, so that the cellular and molecular pathways would be able to induce PAH through specific mechanisms. Although no pathognomonic signs and symptoms have been reported in the literature, the most prominent manifestations of PAH are associated with disorders such as heart failure. Currently, PAH is known as a severe and occasionally life-threatening multifactorial clinical condition. Considering endothelial dysfunction, vasoconstriction, inflammatory reactions, and platelet aggregation as the main pathophysiological arms of the disease, specific treatment approaches have been proposed to inhibit these manifestations. These methods result in the effective treatment response, as well as the proper early and late outcomes of PAH. Due to the high incidence of cardiovascular diseases and the associated progressive life-threatening conditions, such as heart failure and PAH in the Iranian population, identification of the etiological, pathophysiological, diagnostic, and novel therapeutic approaches for PAH is essential to the proper management of this clinical condition.
Milad Ashrafizadeh; Zahra Ahmadi
Abstract
Introduction: Today, smoking has become a common habit, and researchers have largely been concerned with the adverse health effects of smoking. Some approaches have been proposed to minimize these effects. Nicotine is an alkaloid, which is considered to be a detrimental agent in smokers. The present ...
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Introduction: Today, smoking has become a common habit, and researchers have largely been concerned with the adverse health effects of smoking. Some approaches have been proposed to minimize these effects. Nicotine is an alkaloid, which is considered to be a detrimental agent in smokers. The present study aimed to investigate the protective effects of astaxanthin against the adverse effects of nicotine.Methods: In this study, 42 BALB/c male mice were purchased from Mashhad University in Mashhad, Iran and randomly divided into six groups. Group one received one milliliter of normal saline daily, group two received nicotine (1.5 mg/kg), group three was administered with astaxanthin (25 mg/kg), group four also received astaxanthin (50 mg/kg), group five was administered with astaxanthin (25 mg/kg) and nicotine (1.5 mg/kg), and group 6 was administered with astaxanthin (50 mg/kg) and nicotine (1.5 mg/kg). After the experiments, the epididymis was collected, and the motility, viability, and count of the sperms were evaluated.Results: Nicotine at the dose of 1.5 mg/kg decreased the count, viability, and motility of sperm. In contrast, astaxanthin at the doses of 25 and 50 mg/kg was observed to diminish the destructive effects of nicotine.Conclusion: According to the results, astaxanthin is a potent antioxidant for the protection of the reproductive system against nicotine-induced toxicity.
Fargol Nabavi; Javad Akhondian; Sepideh Karkon Shayan; Sepideh Babaniamansour; Raheleh ِDerafshi
Abstract
Introduction: A febrile seizure (FS) occurs in 2-4% of children aged 6 months to 5 years. A simple febrile seizure is the most common seizure in children. According to the evidence, both genetic and environmental factors affect the occurrence of this condition. The purpose of this study was to determine ...
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Introduction: A febrile seizure (FS) occurs in 2-4% of children aged 6 months to 5 years. A simple febrile seizure is the most common seizure in children. According to the evidence, both genetic and environmental factors affect the occurrence of this condition. The purpose of this study was to determine the association between zinc deficiency and sociological factors, and febrile seizures. Methods: This case-control study evaluated 136 children at 22 Bahman Hospital of Gonabad, Iran, from July 2015 to March 2018. We selected 36 children aged 6 months to 5 years with febrile seizures as the case group and 100 febrile children without a seizure, in the same age range, as the control group. The demographic characteristics, place of residence, family history of seizures, and zinc serum level were recorded, and data were analyzed by frequency, average, and standard deviation, and Chi-square statistical tests. The odds ratios were calculated by logistic regression with a 95% confidence level. SPSS version 22.0 was used for statistical analysis. Results: Totally, 38.8% of the cases with FS and 5.0% of the febrile children without seizure had a zinc deficiency. The serum zinc level in the case group was 75.44 ± 16.98 µgr/dL and in the control group was 100.27 ± 24.23 µgr/dL (P < 0.001). The odds ratio of zinc deficiency in the patients with FS compared to the febrile children without convulsion was 1.069 (1.045-1.151). Conclusion: Children with FS are more susceptible to have zinc deficiency than those febrile but without a seizure. Therefore, zinc deficiency could be a preventable and treatable risk factor for FS.
Anuj Singh; Ashish Kumar Sharma; Amit Kumar; Ankit Singh; Swati Khan; Neha Singh Chauhan
Abstract
Introduction: Despite an agricultural country, India confronting malnutrition as a major public health challenge, where every second child is at risk of malnutrition. The nation ranking second in population with disproportionate rural and urban demography, further poor penetration of government assisted ...
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Introduction: Despite an agricultural country, India confronting malnutrition as a major public health challenge, where every second child is at risk of malnutrition. The nation ranking second in population with disproportionate rural and urban demography, further poor penetration of government assisted programs in remote, underserved areas fuelling the malnutrition in rural areas.Methods: This cross-sectional study was conducted in Department of Community Medicine of Rohilkhand Medical College and Hospital. Total 465 schoolchildren in rural and urban areas of Bareilly district were screened for malnutrition and their socio-demographic profiles were studied.Results: Overall, the prevalence of malnutrition in schoolchildren of Bareilly district was 40.2%. Fraction contributed by urban and rural territories was 35.2% and 43%, respectively. The prevalence of malnutrition was found higher in rural area as compared to urban area and the difference was statistically significant (P<0.001).Conclusion: The study shows 43% prevalence of malnutrition in rural areas and under nutrition was the main cause of malnutrition attributed by poverty and illiteracy. However, urban areas reported 7.8% lower prevalence of malnutrition, but alarming trends of overweight and obesity 15.2%.
Soheila Khazaei
Abstract
Background: Approximately 20 million low-birth-weight infants are annually born worldwide. Prematurity and low birth weight are significantly linked to infant mortality rates. Neonates in neonatal intensive care units are often separated from their mothers, leading to a lack of parental involvement in ...
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Background: Approximately 20 million low-birth-weight infants are annually born worldwide. Prematurity and low birth weight are significantly linked to infant mortality rates. Neonates in neonatal intensive care units are often separated from their mothers, leading to a lack of parental involvement in care, which poses numerous risks and threats.Kangaroo mother care has been identified as an alternative method that can mitigate these risks. Methods: This semi-experimental clinical trial examined the effects of independent variables (kangaroo mother care and incubator care) on dependent variables (body temperature, weight gain, exclusive breastfeeding, and physiological measures) in 130 low birth weight infants admitted to the neonatal intensive care unit at Tehran Imam Hussein Hospital during 2019-2020.Results: This study observed an increase in maternal presence at the hospital. There were no significant differences between the two groups of mothers in terms of quantitative variables such as maternal age, number of pregnancies, and length of maternal hospital stay post-delivery. The average duration of kangaroo mother care was 12 ± 8.7 days, No differences were found between the two groups in variables such as gestational age, Apgar score, and weight and height at birth, at stability, and at discharge.Conclusion: This study demonstrated that kangaroo mother care reduces mortality, promotes exclusive breastfeeding, enhances emotional bonding between parents and neonates, reduces sepsis and patent ductus arteriosus, and shortens the duration of antibiotic use. This study supports the development of guidelines for educational programs to incorporate this alternative care method in neonatal intensive care units.
Mahdi Niknazar; Saeid Amel Jamehdar; Majid Khadem-Rezaiyan; zahra ataee
Abstract
INTRODUCTION: there is no clear relationship between the threshold cycle of COVID-19 and severity of pulmonary involvement in the CT scan of patients. Methods: 254 patients were included. The number of cycle of threshold virus, was extracted. The severity of pulmonary involvement was categorized based ...
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INTRODUCTION: there is no clear relationship between the threshold cycle of COVID-19 and severity of pulmonary involvement in the CT scan of patients. Methods: 254 patients were included. The number of cycle of threshold virus, was extracted. The severity of pulmonary involvement was categorized based on the percentage of involvement of each lobe Based on CT scan. The relationship between the CT number and the involvement in the CT scan, was measured.Results: 254 patients with COVID-19 such as 158 (62.2%) men and 96 (37.8%) women with a mean age and standard deviation of 17.785 ± 60.99 years. The average threshold cycle (CT Value) is 5.912 ± 19.38 and it’s minimum and maximum are 9 and 36. The percentage of right lung involvement was 29.7±46.7% and the percentage of left lung involvement was 29.8±47.8%. The number of people without conflict is 6 (2.4) %, with mild conflict 39 (15.4) %, moderate 65 (25.6%) and severe 144 (56.7%). The number of people without involvement of the right lobe is 11 (4.3%), score 1, 42 (16.5%), score 2, 75 (29.5%), score 3, 51 (20.1%), involvement Score 4, 75 (29.5%).The number of people without left lobe involvement is 12 (4.7%), score 1, 46 (18.1%), score 2, 71 (28%), score 3, 48 (18.9%), involvement Score 4, 77 (30.3%) .Conclusion: With the increase of lung involvement, the amount of threshold cycle has decreased, which can indicate the inverse relationship of threshold cycle with the severity of disease involvement.
Farah Ashrafzadeh; Hadi Tohidi; Elnaz Faraji; Alireza Ataei Nakhaei
Abstract
Epilepsy is a major neurological disorder, which may occur in all age groups, including children. Approximately 20% of epileptic children are drug-resistant. Uncontrolled seizures pose variable risks to patients, such as increased mortality rate, trauma, and cognitive and psychiatric disorders. Therefore, ...
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Epilepsy is a major neurological disorder, which may occur in all age groups, including children. Approximately 20% of epileptic children are drug-resistant. Uncontrolled seizures pose variable risks to patients, such as increased mortality rate, trauma, and cognitive and psychiatric disorders. Therefore, effective treatment is essential to controlling seizure attacks. Although many antiepileptic drugs are currently available for clinical treatments, clinicians are concerned with the discovery of safer drugs with enhanced antiepileptic effects and fewer side-effects. Traditional medicine provides strong grounds for modern medicine. Use of some medicinal plants has been shown to reduce or prevent the further progression of epileptic seizures. The present review aimed to discuss the effectiveness of some medicinal plants in the treatment of children with intractable epilepsy. An online literature review was conducted in databases such as IranMedex, Scopus, Medline, and Google Scholar to identify the studies investigating the use of medicinal plants in children with intractable epilepsy. In addition, the files of the authors were reviewed in the reference lists and bibliographies of the retrieved articles. According to the results, herbal therapies could potentially yield new treatment options for children with intractable epilepsy. Using medicinal herbs could be a cost-efficient treatment method in these patients as a culturally acceptable option to their families.
Mahnaz Banihashemi; Solmaz Nakhaeizadeh
Abstract
Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma characterized by haemostatic and tissue repairing effects. Tissue repairing effects and being enriched by various kind of growth factors, has made them the focus of attention for different ...
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Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma characterized by haemostatic and tissue repairing effects. Tissue repairing effects and being enriched by various kind of growth factors, has made them the focus of attention for different procedures. PRP has been effective in bony defects, wound healing and recently for aesthetic procedures in plastic surgery. The purpose of this review is to evaluate and summarize the applications of PRP in the dermatology literature, with particular focus on rejuvenizaton process, advances and limitations of current PRP therapies. We studied literature related to PRP therapy, these include regeneration of soft tissue, skin aging mechanisms, as well as wound healing. Some studies have shown promising results, with favorable outcomes about PRP clinical application for skin rejuvenization. This article summarizes our current understanding regarding photoaging process and the role of PRP in the skin rejuvenization process. PRP has been shown to be useful in skin rejuvenization. Further studies are needed to elucidate both basic and clinical aspects of PRP therapies. In particular, platelet preparation methods, different application methods, platelet mechanism of action in rejuvenation field, interactions with the skin components, long-term efficacy and safety are necessary to be determined.
Alireza Abdollahi Moghaddam; Ali Jangjoo; Fereshteh Ghaderi; Majid Erfanzadeh
Abstract
Introduction: Weight gain and obesity are two important public health problems, which are associated with many diseases such as cardiovascular disorders. Various policies such as bariatric surgery have been proposed for the treatment of morbid obesity. Methods: PubMed and Scopus were searched thoroughly ...
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Introduction: Weight gain and obesity are two important public health problems, which are associated with many diseases such as cardiovascular disorders. Various policies such as bariatric surgery have been proposed for the treatment of morbid obesity. Methods: PubMed and Scopus were searched thoroughly with the following search terms (roux-en-y gastric bypass surgery) AND (ventricular function, OR cardiac risk factors OR heart)) AND (BMI OR body mass index) to find the articles in which the effect of roux-en-Y gastric bypass (RYGB) surgery had been evaluated in severely obese patients.Result: Out of 120 articles which were found in PubMed, and 28 records which were found in Scopus, only 18 articles fully met the inclusion criteria. Out of 2740 participants in the included studied, 1706 were patients with body mass index (BMI) over 40 kg/m2 who had undergone RYGB surgery, and 1034 were control participants. Results of the studies showed that RYGB surgery could reduce BMI, and cardiac risk factors, and improve diastolic function, systolic and diastolic blood pressures, and aortic function, postoperatively.Discussion: Obesity is associated with increased risk of cardiovascular diseases, impaired cardiac function, and hypertension. It is shown that RYGB surgery reduces the serum level of biochemical markers of cardiac diseases. Cardiac structure, parasympathetic indices of autonomic function, coronary circulatory function, hypertension, epicardial fat thickness, and ventricular performance improve after bariatric surgery.Conclusions: It is concluded that RYGB surgery is an effective strategy to improve ventricular function and cardiac risk factors in morbid obese patients.
Masoumeh Sarbaz; Khalil Kimiafar; Majid Khadem-Rezaiyan; Mohammad Javad Ghasri; Mohammad Reza Farhang Far; Yones Bondar Sahebi; Alireza Omranzadeh
Abstract
Introduction: An adverse event (AE) is defined as an intended condition caused by medical errors or during hospitalization. Evidence in this regard is scarce and outdated. The present study aimed to evaluate the prevalence of medical and surgical AEs in three tertiary hospitals in the northeast of Iran.Methods: ...
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Introduction: An adverse event (AE) is defined as an intended condition caused by medical errors or during hospitalization. Evidence in this regard is scarce and outdated. The present study aimed to evaluate the prevalence of medical and surgical AEs in three tertiary hospitals in the northeast of Iran.Methods: This cross-sectional study was conducted on all the admitted patients to three trauma-specialized hospitals affiliated to Mashhad University of Medical Sciences due to AEs (n=1,121) in 2014. Identification of the AEs was accomplished using the International Classification of Diseases 10.Results: The prevalence of AEs was estimated at 1.2%. The mean age of the patients exposed to AEs was 36.5±19.5 years, and 74% of these cases (n=830) were male. The mean length of hospital stay in these patients was 9.8±12.7 days. The majority of the reported AEs (n=1,020; 91%) were caused by surgical and other medical procedures, such as the abnormal reaction of patients, later complication, and not mentioning the misadventure upon the procedure. The mortality rate among the patients was determined to be 2.4%.Conclusion: Although the rate of postoperative complications was relatively low, more strict academic protocols must be exploited in order to prevent AEs, especially in critical periods, such as summer.
Aradhana Bhargava; ASHISH JAIMAN; HITESH LAL; MOHIT KUMAR PATRALEKH
Abstract
Introduction: In this era of social distancing, dependence on electronic gadgets and devices is ever increasing. Possibility of transmission of COVID -19 from these devices cannot be ruled out. Currently, prevention is the only antidote; considering the mounting evidence of transmission of COVID-19 virus ...
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Introduction: In this era of social distancing, dependence on electronic gadgets and devices is ever increasing. Possibility of transmission of COVID -19 from these devices cannot be ruled out. Currently, prevention is the only antidote; considering the mounting evidence of transmission of COVID-19 virus primarily through respiratory droplets and fomites. Gadgets are one of the most frequently touched appliances; being often used during or after patient examination, while handling specimens or during various patient procedures. Collecting data regarding mobile sanitization is prudent at these times. The aim of this systematic review is to summarize published evidence on mobile sanitization in these COVID times.Methods: PubMed search on “COVID and mobile phone” revealed only 4 articles related to this topic; therefore we have assimilated data from various organizations, websites and articles and have suggested methodology for sanitization of mobile phones and other gadgets.Results: Infection control practices which include information, communication, education and evaluation are the pre-eminent weapons in the fight against hospital transmitted SARS-CoV-2. Minimizing mobile phone usage, sanitizing them with endorsed biocidal agents and advancements in the field of ultraviolet cabinets is a priority.Conclusion: At the same time we shouldn’t forget that sanitization is only one aspect of prevention of this disease; maintaining hand hygiene, use of masks and social distancing must be followed at all times.
Maryam Tavakoli; Donya Farrokh
Abstract
Introduction: Magnetic resonance spectroscopy (MRS) is a sensitive and non-invasive imaging method that provides information about the metabolite variations due to pathological damages. In this study, we aimed to systematically review studies in which the MRS had been used for quantitative analysis of ...
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Introduction: Magnetic resonance spectroscopy (MRS) is a sensitive and non-invasive imaging method that provides information about the metabolite variations due to pathological damages. In this study, we aimed to systematically review studies in which the MRS had been used for quantitative analysis of steatohepatitis.Methods: PubMed and Scopus were methodically searched in June 2015 with following search method (((magnetic resonance spectroscopy OR MR spectroscopy OR MRS)) AND (hepatic steatosis OR steatohepatitis OR fatty liver)) AND Quantitative) to find relevant documents in which the diagnostic value of MRS had been investigated in patients with hepatic steatosis. Obtainable information were extracted and used for further evaluation based on the main purpose of this study.Results: Of 88 articles found in the PubMed and 328 found in the Scopus, only 10 relevant documents were selected and used for data extraction according to inclusion/exclusion criteria. Of total 2963 participants enrolled in the selected studies, 1428 were male and 1535 were female. The results of this review showed that MRS is reliable technique for quantitative assessment of steatohepatitis.Conclusion: Findings showed that MRS as a non-invasive imaging method can quantitatively determine even small changes of metabolites due to pathological damages. As well, findings suggested that the results obtained by MR spectroscopy can be considered as reference standard in quantitative analysis. Based on the results of studied documents, MRS as a sensitive tool is helpful in the quantitative assessment of patients with fatty liver disease.
Lahya Afsharisaleh; Nasrin Anvari; Maliheh Dadgarmoghaddam; Bita Kiafar; Farzaneh Rahimpour
Abstract
Introduction: Work related dermatitis is one of the most prevalent diseases, which its economic and social effects on the individual and the society is considerable. The Nordic Occupational Skin Questionnaire (NOSQ-2002) is known as a comprehensive and standardized tools for screening the occupational ...
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Introduction: Work related dermatitis is one of the most prevalent diseases, which its economic and social effects on the individual and the society is considerable. The Nordic Occupational Skin Questionnaire (NOSQ-2002) is known as a comprehensive and standardized tools for screening the occupational skin diseases.The main purpose of this study was to translate and cross-culturally adapt the NOSQ-2002/SHORT into Persian.Materials and methods: A survey cultural translation carried out during 2018 in Mashhad, Iran. The NOSQ-2002/SHORT adaptation process included the forward translation and reconciliation, back translation and an expert panel assessment. The content validity ratio (CVR) and content validity index (CVI) were calculated according the to Lawshe formula. The Persian version of the questionnaire was tested in 30 workers attended the training courses for health ID card confirmation as a pilot study and were confirmed by physical examination. Base on the participants’ opinion, the ambiguous questions were modified by the expert panel. Results: All the 15 questions had a CVR of 0.6 and higher. The overall content validity index of the questionnaire was equal to 0.80. Some obscure words not good understood by the pilot study participants were revised. The results of the questionnaire declaration was matched with the physical examination for each worker.Conclusion: The Persian version of the NOSQ-2002/SHORT questionnaire is now available for researchers for assessment hand eczema in the work settings. Further research is suggested to evaluate the validity of the Persian version of NOSQ-2002.
Susan Shafiei; Reza Bagheri; Kayvan Sadri; Amir Hossein Jafarian; Davood Attaran; Shahrzad Mohammadzadeh Lari; Reza Basiri; Amir Mohammad Hashem Asnaashari; Ramin Sadeghi
Abstract
Introduction: Sentinel node mapping is a new technique of lymph nodal staging in solid tumors, which can decrease the morbidity of regional lymph node dissection considerably. Intra-thoracic tumors including non-small cell lung cancer (NSCLC) and esophageal carcinoma (EC) are among the solid tumors in ...
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Introduction: Sentinel node mapping is a new technique of lymph nodal staging in solid tumors, which can decrease the morbidity of regional lymph node dissection considerably. Intra-thoracic tumors including non-small cell lung cancer (NSCLC) and esophageal carcinoma (EC) are among the solid tumors in which sentinel node (SN) mapping has been applied. In the current systematic review, we gathered the best available evidence (systematic reviews) in this regard and presented the results in a systematic review format.Material and methods: We searched MEDLINE and SCOPUS since the inception till 13 December 2014 using the following keywords: (lung OR esophagus OR esophageal) AND sentinel AND (“systematic review” OR meta-analysis OR metaanalysis). No language limit was imposed on the search strategy. Systematic reviews and meta-analyses on SN mapping in EC or NSCLC were included in the current study. Narrative review articles were excluded from the study.Results: Overall five systematic review were included. One of the included studies was on SN mapping in NSCLC and four were on EC. Overall detection rate and sensitivity for EC and NSCLC were high and both were related to mapping technique, pathological involvement of the mediastinal nodes, size and location of the tumors.Conclusion: SN mapping is feasible and highly accurate in EC and NSCLC. Attention to the technique (using radiotracers, peri-tumoral injection) and restriction of the patients to less advanced cases (cN0 and T1, 2) would ensure the best results with high detection rate and sensitivity.
Behnoush Bakhshoudeh; Maryam Salehi; Ramin Sadeghi; Alireza Omranzadeh; Toktam Sahranavard; Soheil Arekhi; Ali Jafarzadeh Esfehani; Naghmeh Zabolinejad
Abstract
Introduction: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are skin diseases that affect the quality of life. Although a systematic review on LPP and FFA treatment was published in 2013, further updates are needed. The aim of this study is to review systematically the studies published ...
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Introduction: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are skin diseases that affect the quality of life. Although a systematic review on LPP and FFA treatment was published in 2013, further updates are needed. The aim of this study is to review systematically the studies published after the last systematic review.Methods: We searched Scopus, PubMed, Embase, and ISI Web of Science. All the studies published during March 2012-June 2017 were included in this review. Two reviewers separately selected the studies and extracted the data. The results of studies were categorized as unimproved, stabilized, and improved based on the articles reports.Result: Among the 38 studies, 20, 17, and one studies assessed LPP, FFA, and both treatments, respectively. The papers were case reports, case series, cohorts, and randomized controlled trials. Antimalarial agents and pioglitazone resulted in enhancement in 73 and 71% of the LPP patients, respectively. Improvement and stabilization were observed in almost one third of the topical steroid users and 6/12 of Tacrolimus/Pimecrolimus users in LPP. Improvement and stabilization in FFA was found in 68% of the individuals using antimalarial agents, 83% of intralesional steroid users, all cases of finasteride users, and 95% of the people utilizing dutasteride.Conclusion: Contrary to the previous systematic review, we found antimalarial agents more effective than steroids in LPP. Finasteride/dutasteride may have favorable impacts on FFA. Intralesional steroids showed to be more effective than antimalarial agents in FFA. Still further studies are needed in order to define a treatment protocol. Low quality and heterogeneity of the articles were among the limitations for making a conclusion.
Yusuf Baran; Gizem Tuğçe Ulu; Yağmur Kiraz
Abstract
Cancer is defined as uncontrolled cell division, which could spread or invade various tissues. There are more than 200 types of cancer, including breast, skin, lung, colon, and prostate cancer, and lymphoma, the symptoms and indications of which vary depending on the type of tissues. Cancer has several ...
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Cancer is defined as uncontrolled cell division, which could spread or invade various tissues. There are more than 200 types of cancer, including breast, skin, lung, colon, and prostate cancer, and lymphoma, the symptoms and indications of which vary depending on the type of tissues. Cancer has several treatments with different applications. For instance, chemotherapy, radiation therapy, surgery or their combination are common treatment modalities for cancer. However, a complete cure for cancer has not been achieved yet. On the other hand, novel drugs for cancer treatment are not efficient due to the ability of cancer cells to develop resistance against chemotherapeutic agents. Recently, natural compounds have been reported to improve the efficiency of cancer treatment. Polyunsaturated fatty acids (PUFAs) are natural compounds that could be used as dietary supplements in cancer patients. PUFAs are classified into two main categories, including n-3 and n-6 PUFAs. According to the literature, n-3 PUFAs exert protective effects against cancer through the induction of apoptotic pathways and suppressing cell proliferation, while n-6 PUFAs cause tumor formation by inducing cell growth and proliferation. Using PUFAs in combination with chemotherapeutic agents is considered to be an effective approach to the treatment of cancer patients through increasing cancer cell death. This review aimed to discuss the interactive effects of the structure and function of PUFAs on cancer and cell processes through various signaling pathways.
Farhad Heydarian; Hamid Ahanchian; Maryam Khalesi; Saeed Ebrahimi
Abstract
Introduction: Asthma is a chronic inflammatory airway disorder that is distinguished by coughing, wheezing, and dyspnea. It is the most common chronic disease among children. Epidemiological trials have suggested that there may be a correlation between vitamin C intake and the incidence of asthma. Specifically, ...
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Introduction: Asthma is a chronic inflammatory airway disorder that is distinguished by coughing, wheezing, and dyspnea. It is the most common chronic disease among children. Epidemiological trials have suggested that there may be a correlation between vitamin C intake and the incidence of asthma. Specifically, according to these studies, a rapid increase in the occurrence of asthma may be caused by a decreased intake of dietary antioxidants and various vitamins such as vitamin C. A systematic review was performed to determine the role that vitamin C, in terms of both dietary intake and serum levels, had on asthma in children. Methods: PubMed and Scopus databases were searched for studies that provide information on the effects of vitamin C on asthma in children aged between 1 and 17 years. The inclusion criteria specified that the studies involved needed to be cohort and case series involving at least ten patients. Exclusion criteria were non-English articles, case reports, and articles involving children who were aged below or above the age 1 and 17 respectively.Result: A total of 13 studies involving 6503 patients met the inclusion criteria. Dietary vitamin C intake was lower in people with asthma than in those without asthma. Lower quantity dietary intakes and serum levels of vitamin C were also associated with increased incidents of asthma.Conclusion: According to the extracted data, a relatively low dietary intake of vitamin C is associated with an increased risk of asthma and wheezing. Moreover, asthmatic patients who consumed vitamin C exhibited an improvement in their diseases.
Negareh Yazdani; Leyla Shahkarami; Javad Heravian Shandiz; Veda Vakili; Hadi Ostadimoghaddam; AbbasAli Yekta; Seyed Hosein Hoseini-Yazdi
Abstract
Introduction: This article aimed to review the literatures on visual impairments and ocular changes in premature infants with low birth weight and gestational age.Methods: Five electronic databases including: PubMed, Web of Science, Science direct, Ovid, and Scopus were searched. Original articles published ...
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Introduction: This article aimed to review the literatures on visual impairments and ocular changes in premature infants with low birth weight and gestational age.Methods: Five electronic databases including: PubMed, Web of Science, Science direct, Ovid, and Scopus were searched. Original articles published until 2015 describing preterm infants were reviewed. Repetitive and derivative articles were excluded.Results: Out of 100 unique, potentially relevant articles, 42 studies that addressed and met the inclusion criteria were evaluated.Conclusion: Prematurity affects ocular structures (from anterior to posterior segment) and functions. Premature infants are at risk of myopization. Concerning the changes in premature infants, a significant increase is found in axial length, intraocular pressure, and central corneal thickness; moreover, high incidence of retinal changes is reported as a result of prematurity. On the other hand, visual acuity, tear, electroretinogram, and visual evoked potential responses decrease with prematurity. The most common ophthalmic disorders in preterm infants are myopia and retinopathy of prematurity, which could affect life quality due to reduced visual acuity.
Ali Dehghani; Habib Jafari; Naser Shoeibi
Abstract
Intravitreal injections of anti-vascular endothelial growth factors (anti-VEGFs) have become more popular quickly in recent years. Bevacizumab is an anti- vascular endothelial growth factor agent (anti-VEGF) used to treat choroidal neovascularization and retinal vascular disorders. Rare long lasting ...
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Intravitreal injections of anti-vascular endothelial growth factors (anti-VEGFs) have become more popular quickly in recent years. Bevacizumab is an anti- vascular endothelial growth factor agent (anti-VEGF) used to treat choroidal neovascularization and retinal vascular disorders. Rare long lasting ocular adverse events are reported in the intravitreal injection of this drug that include intraocular inflammation, retinal tears, vitreous hemorrhage, endophtalmitis, and lens changes. One important concern about intravitreal injection of anti-VEGF drug is intraocular pressure (IOP) elevation. There are two kinds of IOP elevation. First one is an acute elevation of IOP (after few minutes) and the second is delayed IOP elevation (after few months). The prevalence of IOP elevation immediately after injection is significantly high and seems to have the potential risk for optic nerve fiber loss results in decreased vision but fortunately this IOP elevation seems to be transient in most of studies.
Elhan Bakhtiari; Farhad Heydarian; Mohammad Ali kiani; Zahra Askari; Mohammad Heidarian
Abstract
Objective: The aim of present study was evaluation and comparison of the white blood cell, erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) in febrile children with or without convulsion. Methods: Three hundred sixty eight febrile children aged 6-60 months with or without convulsion ...
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Objective: The aim of present study was evaluation and comparison of the white blood cell, erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) in febrile children with or without convulsion. Methods: Three hundred sixty eight febrile children aged 6-60 months with or without convulsion were studied. Demographic, white blood cell (WBC), ESR and CRP were compared and analyzed. Results: There was 368 children (184 patients with febrile convulsion as case group and 184 febrile patients without convulsion as control group), with the average age of 26.6±14.4 months and 17.71±15.4 months respectively (p=0.001). In case group 59.78% and in control group 43.48% were male (p=0.002). There was no significant difference between groups regarding WBC, ESR and CRP. There was significant relationship between leukocytosis and convulsion in patients with longer than 15 minutes convulsion (p=0.03). There was not any significant relationship between febrile convulsion patients according to type, duration and frequency of convulsion in ESR and CRP. Conclusion: Leukocytosis and elevated ESR and CRP in patients with febrile convulsion can represent underlying etiology of the fever and it may not be due to convulsion itself. But in longer than 15 minutes convulsion, it can lead to leukocytosis itself.
Fariba Zemorshidi; Reza Boostani; Mohammad Mehdi Etemadi
Abstract
Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis is a chronic progressive neurologic disease, which might be associated with brain and spinal cord atrophy and lesions. Here, we systematically reviewed the brain and spinal cord abnormalities ...
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Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis is a chronic progressive neurologic disease, which might be associated with brain and spinal cord atrophy and lesions. Here, we systematically reviewed the brain and spinal cord abnormalities reported by magnetic resonance imaging (MRI) modality on HTLV-1-associated myelopathy/tropical spastic paraparesis patients. Methods: PubMed was searched for all the relevant articles, which used MRI in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. Included criteria were all the cohort and case series with at least 10 patients. We had no time limitation for searched articles, but only English language articles were included in our systematic review. Exclusion criteria were none-English articles, case reports, articles with less than 10 patients, spastic paraparesis patients with unknown etiology and patients with HTLV-II. Results: Total of 14 relevant articles were extracted after studying title, abstracts and full text of the irrelevant articles. Only 2/14 articles reported brain atrophy incidence. Five out of 14 articles studied the brain lesions prevalence. Spinal cord atrophy and lesions were studied in 6/14 articles.Discussion: According to the extracted data, brain atrophy does not seem to happen frequently in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis. None-specific brain lesions identified in articles are indicative of low specificity of MRI technique despite its high sensitivity. Conclusion: Prevalence of spinal cord lesions and atrophy in these patients might be due to the degenerative processes associated with aging phenomenon. Further and larger studies in endemic areas could more accurately reveal the specificity of MRI in these patients.