Effect of Hyperbaric Oxygen Therapy on Diabetic Foot Ulcer; a clinical study

Document Type : Original article


1 School of Medicine, Islamic Azad University Tehran Faculty of Medicine, Tehran, Iran

2 School of Medicine, Islamic Azad University Tehran Faculty of Medicine, Tehran, Iran.

3 School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.

5 Assistant professor of Orthopedic Department, Islamic Azad University Tehran Faculty of Medicine, Tehran, Iran.


Introduction: Diabetic foot ulcer (DFU) is one of the most common diabetes complications. Beside conventional treatments, Hyperbaric oxygen therapy (HBOT) has been used as an adjunctive therapy for DFU. This study aimed to assess the efficacy of HBOT and possible associated factors.
Methods: This study was conducted at hyperbar Bahar and Khatam clinics, in Isfahan and Tehran, Iran during September 2016 and September 2017. Eligible participants underwent 100% oxygen at 2 to 2.5 Atmosphere Absolute for 90 to 120 minutes, daily (five days per week). Data was analyzed with SPSS Version 24.0.
Results: The recovery rate was (69%), in 58 enrolled patients and had significant direct association with good glycemic control status, before (p <0.01) and during HBOT (p <0.01), and low-grade ulcers (p=0.04). Mean HBOT sessions of cured patients (21.5±17.1) was significantly higher than not cured patients 11.3±7.9 (p=0.02). However, recovery rate had no significant association with types of ulcer (p=0.1).
Conclusion: HBOT had good efficacy and high recovery rate in DFU treatment. Given the fact that good glycemic control status reduces the incidence of ulcers, this study showed that it increased the DFU recovery rate under HBOT.


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