Document Type : Original article


1 Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


Introduction:In the present study, we evaluated the 4-year antimicrobial resistance trends of several nosocomial pathogens during 2018-2021 in a reffereal Mashhad hospital, Mashhad, Iran.
Methods:In this study, we reviewed the data of 70,234 clinical isolates were registred Infection Control Data of Ghaem Hospital, Mashhad, Iran. The antimicrobial susceptibility testing was performed using Kirby-Bauer disk diffusion method according to clinical and laboratory standard institute (CLSI) instructions to evaluate trends of antimicrobial resistance over the times.
Results: There were identified (A. baumannii: n = 19,374; K. pneumonia n = 17,206; E. coli n = 23,777; S. epidermidis: n = 9,877). We did not find any significant difference in changes of antimicrobial trends over the time except in minor cases . However, The pattern of antimicrobial drug resistance was gradually differed except E. coli.
Conclusion: our results suggested the overall antimicrobial resistance trends was remins the same level during 2018-2021. It seems that in accessibility and stop prescribing of antibiotics can lead to decreasing antibiotic resistance rate.


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