Document Type : Systematic review
Authors
1 Student Research Committee, Islamic Azad University, Mashhad Branch, Mashhad, Iran
2 Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Community Medicine, Mashhad Medical Science Branch, Islamic Azad University, Mashhad, Irances
4 Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Introduction: Small nucleolar RNA host genes (SNHGs) are a class of long non-coding RNAs that have been increasingly associated with various cancers and are emerging as key players in cancer progression.This systematic review aimed to analyze the expression patterns and potential roles of SNHG5, SNHG17, and SNHG26 in various solid tumors.
Methods: A comprehensive literature search was conducted across databases including PubMed, Cochrane, and Google Scholar, to identify relevant studies. Initially retrieved papers were screened based on titles and abstracts for relevance, with exclusion criteria applied to eliminate duplicate publications, case reports, conference abstracts, and irrelevant studies.
Results: A total of 21 papers met the criteria for this systematic review, focusing on SNHG5 (5 articles), SNHG17 (7 articles), and SNHG26 (9 articles). These studies consistently highlighted the upregulation of SNHG5, SNHG17, and SNHG26 in various cancer types, emphasizing their potential as prognostic and therapeutic targets in solid tumors.
Conclusion: The findings suggest a consistent overexpression of SNHG5, SNHG17, and SNHG26 in cancerous tissues, supporting their potential as prognostic markers in solid tumors. Further investigations should consider the regulatory mechanisms of SNHGs and explore their therapeutic implications in cancer management. This review highlights the importance of understanding the roles of SNHGs in cancer progression and calls for continued research efforts.
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